Document Detail

Acute effects of tea on fasting and non-fasting plasma total homocysteine concentrations in human subjects.
MedLine Citation:
PMID:  17408524     Owner:  NLM     Status:  MEDLINE    
Plasma total homocysteine concentrations (tHcy) are a putative risk factor for CVD. Tea is a rich dietary source of polyphenols and caffeine, both of which may raise tHcy. However, it is possible that much of any effect is transitory and may be influenced by the consumption of food. Our objective was to investigate the acute effect of tea, at a dose representative of ordinary population intakes, on tHcy and to determine whether consumption of a meal influences the magnitude of any effect. Measurements of tHcy were performed in twenty participants at baseline and 3.5 h after drinking three cups of black tea or hot water (consumed at time 0, 1.5 and 3 h) with and without a meal: a total of four treatments administered in random order. Drinking tea resulted in an acute increase in tHcy (0-30 (95 % CI 0.04, 0.56) micromol/l, P=0.022). The meal resulted in an acute decrease in tHcy (-0.42 (95 % CI -0.68, -0.16) micromol/l, P=0.002). There was no interaction between tea and meal on tHcy (P=0.40); that is, the effect of tea on tHcy was not different in the fasting and non-fasting state. Our results suggest that drinking black tea can cause a small acute increase in tHcy and that this effect is not enhanced in the non-fasting state. Given that results of population studies have generally shown a negative association between tea intake and tHcy, the significance of these findings to CVD risk remains uncertain.
Jonathan M Hodgson; Ian B Puddey; Frank M van Bockxmeer; Valerie Burke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  97     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-09-05     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  842-6     Citation Subset:  IM    
University of Western Australia, School of Medicine and Pharmacology at Royal Perth Hospital, and the Western Australian Institute for Medical Research, Perth, Australia.
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MeSH Terms
Biological Markers / urine
Caffeine / blood
Cross-Over Studies
Drinking / physiology
Eating / physiology
Fasting / blood*
Flavonoids / metabolism
Folic Acid / blood
Gallic Acid / analogs & derivatives,  urine
Homocysteine / blood*
Middle Aged
Phenols / metabolism
Tea / metabolism*
Vitamin B 12 / blood
Reg. No./Substance:
0/Biological Markers; 0/Flavonoids; 0/Phenols; 0/Tea; 0/polyphenols; 149-91-7/Gallic Acid; 4319-02-2/3,5-dihydroxy-4-methoxybenzoic acid; 454-28-4/Homocysteine; 58-08-2/Caffeine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

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