Document Detail


Acute effects on systemic and pulmonary hemodynamics of intratracheal instillation of porcine surfactant or saline in surfactant-depleted newborn piglets.
MedLine Citation:
PMID:  9098849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Surfactant instillation may affect systemic and pulmonary hemodynamics. The aim of this study was to investigate whether this effect is specific to surfactant or if it can be triggered by instillation of the same volume of saline. Piglets 3-5-d-old were subjected to repeated lung lavage using 20 mL/kg 0.9% saline until the partial pressure of arterial O2 was < 10 kPa and partial pressure of arterial CO2 was between 4.0 and 6.0 kPa with fraction of inspired oxygen (FiO2) 1.0 and peak inspiratory pressure 25 cm H2O. Porcine surfactant 200 mg/kg (80 mg/mL) or the same volume of 0.9% saline was instilled into the lungs through a feeding catheter entered through the endotracheal tube. Mean arterial blood pressure, pulmonary artery pressure, and cardiac output were measured continuously. There was a significant decrease in mean arterial blood pressure from 67 (+/- 13) mm Hg to 52 (+/- 18) mm Hg (p < 0.05) 210 s after instillation of surfactant. Systemic vascular resistance decreased from 0.42 (+/- 0.18) to 0.34 (+/- 0.18) mm Hg x mL-1 x min x kg (p < 0.05) from 0 min to 180 s after instillation of surfactant. In the group receiving saline instillations there were no significant changes in mean arterial blood pressure or systemic vascular resistance. A transient but significant increase in mean pulmonary artery pressure was seen 120 s after instillation in both groups with a return to presurfactant level 240 s after instillation. Pulmonary vascular resistance increased transiently and significantly only in the group receiving surfactant. We conclude that porcine surfactant causes a decrease in systemic vascular resistance, resulting in a decrease in mean arterial blood pressure in newborn lung-lavaged piglets not seen after instillation of the same volume of saline.
Authors:
A Moen; X Q Yu; T Rootwelt; O D Saugstad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  41     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-02     Completed Date:  1997-07-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  486-92     Citation Subset:  IM    
Affiliation:
Department of Pediatric Research, Rikshospitalet, Oslo, Norway.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Blood Pressure / drug effects
Drug Evaluation, Preclinical
Hemodynamics / drug effects*
Instillation, Drug
Intubation, Intratracheal
Pulmonary Artery / drug effects
Pulmonary Surfactants / metabolism,  pharmacology*
Sodium Chloride / pharmacology*
Swine
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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