Document Detail

Acute effects of simvastatin to terminate fast reentrant tachycardia through increasing wavelength of AVNRT circuit.
MedLine Citation:
PMID:  24990322     Owner:  NLM     Status:  Publisher    
Simvastatin (SV) leads to reduction of ventricular rhythm during atrial fibrillation on rabbit atrioventricular (AV) nodes. The aim of our study was (i) to determine the frequency-dependent effects of SV in a functional model, and (ii) to assess the effects of SV to suppress experimental atrioventricular nodal reentrant tachycardia (AVNRT). Selective stimulation protocols were used with two different pacing protocols, His to atrial (HA) and atrial to atrial (AA). An experimental AVNRT model with various cycle lengths was created in three groups of perfused rabbit AV nodal preparations (N = 24) including: SV 3 μM, SV 7 μM, and verapamil 0.1 μM. SV increased nodal conduction time and refractoriness by AA pacing. Different simulated models of slow/fast and fast/slow reentry were induced. SV caused inhibitory effects on the slow anterograde conduction (origin of refractoriness) more than on the fast anterograde conduction time, leading to an increase of tachycardia cycle length, tachycardia wavelength and termination of slow/fast reentrant tachyarrhythmia. Verapamil significantly suppressed the basic and frequency-dependent intrinsic nodal properties. In addition, SV decreased the incidence of gap and echo beats. The present study showed that SV in a concentration and rate-dependent manner increased the AVERP and reentrant tachycardia wavelength that lead to slowing or termination of experimental fast AVNRT. The directed-dependent inhibitory effect of SV on the anterograde and retrograde dual pathways explains its specific anti-reentrant actions. This article is protected by copyright. All rights reserved.
Vahid Khori; Ali Mohammad Alizadeh; Hamid Reza Mohemani; Mahdi Zahedi; Soroosh Aminolsharieh Najafi; Delaram Shakiba; Mohsen Nayebpour
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-3
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  -     ISSN:  1472-8206     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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