| Acute effects of pharmacotherapies in blood pressure in normotensive moderate smokers. | |
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MedLine Citation:
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PMID: 19919396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to evaluate the changes in arterial blood pressure (BP) and heart rate (HR) in moderate smokers during smoking abstinence after 7 days of treatment with bupropion alone, transdermal nicotine or bupropion combined with transdermal nicotine. Twenty-four healthy moderate smokers (12 female/12 male; 40+/-7 years) were evaluated randomly on five occasions and their systolic, diastolic, mean arterial blood pressure (MAP) and HR were measured by a Finapres device for 10 h, immediately after smoking interruption. All of the 24 smokers participated on five protocols during 7 days: control group (C) - no drugs; placebo group (PL); bupropion group (BUP) 150-300 mg; transdermal nicotine group (TN) - 21 mg; and BUP+TN-nicotine patch. Concomitantly, the subjects were evaluated by ABPM (ambulatory BP monitoring). All of BP parameters monitored shown significant statistical differences in the BUP, TN and BUP+TN groups compared with the controls (p<0.05), when measured by Finapres. The HR remained unaltered in all of the groups. No significant differences were seen in the BP or HR during the 24-h ABPM. These findings indicate that in moderate smokers, bupropion, transdermal nicotine or bupropion associated with transdermal nicotine caused an elevation in the BP after acute smoking interruption. |
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Authors:
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Lu??z Cl??udio Martins; S??lvia Elaine Ferreira-Melo; Maricene Sabha; Ot??vio Rizzi Coelho; Juan Carlos Yugar-Toledo; Thiago Quinaglia; Marcos Mello Moreira; Antonio Coca; Heitor Moreno J??nior |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood pressure Volume: 18 ISSN: 1651-1999 ISO Abbreviation: Blood Press. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-11-20 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: England |
Other Details:
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Languages: eng Pagination: 255-60 Citation Subset: IM |
Affiliation:
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Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects* Bupropion / administration & dosage*, adverse effects Cross-Over Studies Female Heart Rate / drug effects Humans Male Middle Aged Nicotine / administration & dosage*, adverse effects Single-Blind Method Smoking / physiopathology* Smoking Cessation / methods* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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34841-39-9/Bupropion; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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