| Acute effects of lamotrigine (BW430C) in persons with epilepsy. | |
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MedLine Citation:
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PMID: 3698937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixteen epileptic patients took single doses of lamotrigine, 120 mg or 240 mg. Six photosensitive patients showed reduction (with abolition in two) in photosensitivity after lamotrigine administration. Five subjects with frequent interictal spikes showed reduction in spike frequency over 24 h after lamotrigine administration. The half-life (t1/2) of lamotrigine in subjects taking sodium valproate was prolonged, whereas the t1/2 in subjects taking carbamazepine and/or phenytoin was reduced. The area under the curve of co-medication plasma levels was not affected by a single dose of lamotrigine. Five patients reported mild and generally transitory side effects; some of which represented exacerbation of preexisting complaints. |
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Authors:
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C D Binnie; W van Emde Boas; D G Kasteleijn-Nolste-Trenite; R A de Korte; J W Meijer; H Meinardi; A A Miller; J Overweg; A W Peck; A van Wieringen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsia Volume: 27 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 1986 May-Jun |
Date Detail:
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Created Date: 1986-06-24 Completed Date: 1986-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 248-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Epilepsy / drug therapy* Female Half-Life Humans Male Metabolic Clearance Rate Middle Aged Photosensitivity Disorders / chemically induced Triazines / adverse effects*, metabolism, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Triazines; 84057-84-1/lamotrigine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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