Document Detail

Acute effects of intratracheal administration of platelet-activating factor in baboons.
MedLine Citation:
PMID:  6629917     Owner:  NLM     Status:  MEDLINE    
The bronchomotor effect of intratracheal administration of PAF-acether (60 micrograms X kg -1) was investigated in 37 curarized baboons mechanically ventilated with constant volume and frequency. PAF-acether caused an immediate bronchoconstriction as assessed by a marked increase in peak inspiratory pressure with no change in static pulmonary compliance and chest X-rays. There was a concomitant fall in arterial PO2 and a significant increase in ventilated unperfused lung zones. A decrease of circulating platelets and leucocytes was also observed. Local anesthesia with lidocaine and atropine did not prevent PAF-acether-induced bronchoconstriction although both markedly reduced the bronchial response to histamine. Albuterol significantly reduced the bronchial response to PAF-acether. Pretreatment with aspirin (80 mg X kg -1 iv) did not prevent the bronchoconstriction caused by PAF-acether, and intravenous or intratracheal arachidonic acid caused no bronchial response. Thus the role of cyclooxygenase metabolites of arachidonic acid in PAF-acether-induced bronchoconstriction is unlikely. In conclusion, an acute bronchoconstriction probably not triggered by stimulation of irritant receptors of the airways and associated with aggregation of platelet takes place subsequent to intratracheal administration of PAF-acether. These data suggest that PAF-acether might play a role in the pathogenesis of human asthma.
A Denjean; B Arnoux; R Masse; A Lockhart; J Benveniste
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  55     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  799-804     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Local
Aspirin / pharmacology
Atropine / pharmacology
Bronchi / immunology
Bronchial Spasm / immunology
Papio / physiology*
Platelet Activating Factor / administration & dosage*,  immunology
Time Factors
Reg. No./Substance:
0/Platelet Activating Factor; 137-58-6/Lidocaine; 50-78-2/Aspirin; 51-55-8/Atropine

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