Document Detail


Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats.
MedLine Citation:
PMID:  12755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasma insulin concentrations in fed rats were altered acutely by administration of glucose or anti-insulin serum. Rates of fatty acid synthesis in adipose tissue and liver were estimated from the incorporation of 3H from 3H2O. In the adipose tissue dehydrogenase and acetyl-CoA carboxylase were evident. In liver, although changes in rates of fatty acid synthesis were found, the initial activity of pyruvate dehydrogenase did not alter, but small parallel changes in acetyl-CoA carboxylase activity were observed.
Authors:
D Stansbie; R W Brownsey; M Crettaz; R M Denton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  160     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2010-08-31    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  413-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetyl-CoA Carboxylase / metabolism*
Adipose Tissue / enzymology,  metabolism*
Animals
Fatty Acids / biosynthesis*
Glucose / pharmacology
Insulin / blood*,  immunology
Ligases / metabolism*
Liver / enzymology,  metabolism*
Male
Pyruvate Dehydrogenase Complex / metabolism*
Rats
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Pyruvate Dehydrogenase Complex; 11061-68-0/Insulin; 50-99-7/Glucose; EC 6.-/Ligases; EC 6.4.1.2/Acetyl-CoA Carboxylase
Comments/Corrections

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