Document Detail


Acute effects of a high-fat meal with and without red wine on endothelial function in healthy subjects.
MedLine Citation:
PMID:  10498135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that a high-fat meal may acutely impair endothelium-dependent vasodilation and that this impairment may be prevented by concomitant intake of antioxidants. Because red wine contains antioxidant polyphenols and may reduce cardiovascular disease, we examined the effect of red wine on postprandial endothelial function. Using a crossover design, 13 healthy volunteers consumed a high-fat meal (0.8 g fat/kg body weight) with red wine (3 ml/kg) or an isocaloric control beverage on 2 separate days, 1 week apart. Flow-mediated dilation of the brachial artery was examined by vascular ultrasound at baseline and at 2, 4, and 6 hours after the meal. At these times, flow-mediated dilation with the high-fat meal and control beverage was 9.5 +/- 5.0%, 7.9 +/- 5.1%, 6.8 +/- 3.6%, and 7.3 +/- 4.6%, respectively (nonsignificant trend). There was also a nonsignificant trend for flow-mediated dilation after the high-fat meal with wine: 8.0 +/- 4.1%, 5.7 +/- 4.7%, 6.4 +/- 3.1%, and 6.9 +/- 3.8%, respectively. There was no difference in the effects between wine and the control beverage (p = 0.77). Triglycerides increased 2- to 2.7-fold over baseline (p = 0.0001) with a peak occurring 5 hours after the high-fat meals. In contrast to previous studies, the present study did not demonstrate a significant effect of a high-fat meal on endothelial vasomotor function in healthy subjects. Under these conditions, we did not demonstrate a beneficial acute effect of red wine on endothelial function.
Authors:
L Djoussé; R C Ellison; C E McLennan; L A Cupples; I Lipinska; G H Tofler; N Gokce; J A Vita
Related Documents :
21062835 - Number of meals eaten in relation to weight status among norwegian adolescents.
17659795 - Supplements of l-arginine attenuate the effects of high-fat meal on endothelial functio...
21776465 - Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre poly...
8307095 - Human intestinal alkaline phosphatase--release to the blood is linked to lipid absorpti...
3108405 - A fish oil diet inhibits amyloid p component (ap) acute phase responses in arthritis su...
22247015 - A history of cranial radiotherapy is associated with a higher visceral to subcutaneous ...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  84     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-06     Completed Date:  1999-10-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  660-4     Citation Subset:  AIM; IM    
Affiliation:
Section of Preventive Medicine and Epidemiology, Evans Memorial Department of Medicine, Boston University School of Medicine, Massachusetts, USA. ldjousse@bu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity / drug effects
Brachial Artery / drug effects,  ultrasonography
Cross-Over Studies
Dietary Fats / metabolism*
Echocardiography, Doppler, Pulsed
Endothelium, Vascular / drug effects*
Female
Humans
Male
Nitroglycerin / diagnostic use
Vascular Resistance / drug effects
Vasodilator Agents / diagnostic use
Wine*
Grant Support
ID/Acronym/Agency:
HL 53398/HL/NHLBI NIH HHS; M01RR00533/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Vasodilator Agents; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of simvastatin treatment on the electronegative low-density lipoprotein present in patients w...
Next Document:  Usefulness of tilt test-induced patterns of heart rate and blood pressure using a two-stage protocol...