Document Detail

Acute effects of glibenclamide on reactive hyperaemia in the lower limbs in humans.
MedLine Citation:
PMID:  12237477     Owner:  NLM     Status:  MEDLINE    
Three episodes of 1 min ischemia in the lower limbs in humans reduced the metabolic debt repayment (expressed as AUC of reactive hyperaemia) following more prolonged ischemia (666.6+/-86.6 vs 500.0+/-33.5 ml/100 ml). The administration of the ATP-dependent K(+) channel blocker glibenclamide was associated with a significant reduction in the AUC of reactive hyperaemia (666.6+/-86.6 vs 563.1+/-76.6 ml/100 ml), and with the removal of the protective effect produced by 3 episodes of 1 min ischemia (563.1+/-76.6 vs 551.8+/-71.3 ml/100 ml). Plasma level of glibenclamide reached the peak value of 1.295+/-0.15 micromol/l 2 h after drug administration, ranging around the 1 micromol/l concentration in the following 3 hours. Our findings produce indirect evidence that, similarly to the ischemic preconditioning of the heart, the protective effects towards ischemia of brief repeated episodes of sub-maximal occlusion in the peripheral circulation of the lower limbs in humans are mediated by ATP-dependent K(+) channels.
P L Capecchi; F Guideri; M Colafati; M Acampa; A Cuomo; P E Lazzerini; F Laghi Pasini
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  27     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2002  
Date Detail:
Created Date:  2002-09-18     Completed Date:  2003-06-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Department of Clinical Medicine and Immunologcal Sciences, Section of Immunology, University of Siena, Italy.
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MeSH Terms
Area Under Curve
Glyburide / blood,  pharmacokinetics*,  pharmacology
Hyperemia / drug therapy*,  prevention & control
Ischemic Preconditioning / methods
Lower Extremity / pathology*
Middle Aged
Potassium Channel Blockers / blood,  pharmacokinetics*,  pharmacology
Reg. No./Substance:
0/Potassium Channel Blockers; 10238-21-8/Glyburide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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