| Acute effects of doxorubicin on human left ventricular systolic and diastolic function. | |
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MedLine Citation:
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PMID: 2816709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the long-term cardiotoxic effects of cumulative doses of doxorubicin are well established, the short-term effects on cardiac function are uncertain. Therefore we examined the short-term effects of doxorubicin on left ventricular systolic and diastolic function following a total of 56 doses of doxorubicin in 15 patients with normal resting left ventricular function. Resting radionuclide ventriculography was performed 1 hour before and 4 hours after each dose of doxorubicin. Left ventricular ejection fraction increased significantly from 64 +/- 1% to 67 +/- 1% (p less than 0.001) after doxorubicin. In addition, peak ejection rate (p less than 0.005) and peak filling rate (p less than 0.0005) increased significantly following short-term doxorubicin administration. There was no relationship between either the individual or cumulative dose of doxorubicin and the acute ejection fraction, peak ejection rate, or peak filling rate response. Our data suggest that doxorubicin acutely increases left ventricular systolic and diastolic function. |
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Authors:
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K A Brown; A J Blow; R M Weiss; J A Stewart |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 118 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1989-12-05 Completed Date: 1989-12-05 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 979-82 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Vermont College of Medicine, Burlington. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Coronary Circulation / drug effects Diastole Doxorubicin / pharmacology* Female Heart / drug effects*, physiology, radionuclide imaging Humans Male Middle Aged Radionuclide Ventriculography Stroke Volume / drug effects Systole Time Factors |
| Chemical | |
Reg. No./Substance:
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23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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