Document Detail

Acute effects of doxorubicin on human left ventricular systolic and diastolic function.
MedLine Citation:
PMID:  2816709     Owner:  NLM     Status:  MEDLINE    
Although the long-term cardiotoxic effects of cumulative doses of doxorubicin are well established, the short-term effects on cardiac function are uncertain. Therefore we examined the short-term effects of doxorubicin on left ventricular systolic and diastolic function following a total of 56 doses of doxorubicin in 15 patients with normal resting left ventricular function. Resting radionuclide ventriculography was performed 1 hour before and 4 hours after each dose of doxorubicin. Left ventricular ejection fraction increased significantly from 64 +/- 1% to 67 +/- 1% (p less than 0.001) after doxorubicin. In addition, peak ejection rate (p less than 0.005) and peak filling rate (p less than 0.0005) increased significantly following short-term doxorubicin administration. There was no relationship between either the individual or cumulative dose of doxorubicin and the acute ejection fraction, peak ejection rate, or peak filling rate response. Our data suggest that doxorubicin acutely increases left ventricular systolic and diastolic function.
K A Brown; A J Blow; R M Weiss; J A Stewart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  118     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-05     Completed Date:  1989-12-05     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  979-82     Citation Subset:  AIM; IM    
Department of Medicine, University of Vermont College of Medicine, Burlington.
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MeSH Terms
Coronary Circulation / drug effects
Doxorubicin / pharmacology*
Heart / drug effects*,  physiology,  radionuclide imaging
Middle Aged
Radionuclide Ventriculography
Stroke Volume / drug effects
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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