Document Detail

Acute effects of delta-9-tetrahydrocannabinol in rhesus monkeys as measured by performance in a battery of complex operant tests.
MedLine Citation:
PMID:  2834536     Owner:  NLM     Status:  MEDLINE    
Acute effects of delta-9-tetrahydrocannabinol (THC) were assessed using a battery of food-reinforced complex operant tasks that included responding under delayed matching to sample (DMTS, n = 6), conditioned position response (CPR, n = 8) progressive ratio (PR, n = 8), temporal response differentiation (TRD, n = 3) and incremental repeated acquisition (IRA, n = 9) tasks. THC (0.003-0.3 mg/kg i.v.) given 15-min presession produced dose-dependent decreases in the number of reinforcers obtained in each task. TRD accuracy was decreased significantly at doses as low as 0.03 mg/kg, making TRD accuracy the most sensitive parameter measured. For PR, the break-point (number of responses emitted for the last reinforcer earned) was decreased significantly only at 0.3 mg/kg. Significant disruptions of performance in schedules other than PR were evident at doses of 0.1 mg/kg and above: response rates decreased or latencies to respond increased. Accuracy of responding was not altered in the IRA, DMTS or CPR tests at doses less than those that decreased response rates. The relative sensitivities of these tests for detecting THC behavioral effects were thus TRD greater than IRA = DMTS = CPR greater than PR. These results indicate that THC, at doses that produce plasma levels similar to those noted in humans after marijuana smoke exposure, produce acute behavioral effects on temporal differentiation in monkeys analogous to some effects reported in humans.
G E Schulze; D E McMillan; J R Bailey; A Scallet; S F Ali; W Slikker; M G Paule
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  245     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-06-02     Completed Date:  1988-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-86     Citation Subset:  IM    
Pharmacodynamics Branch, National Center for Toxicological Research, Jefferson, Arkansas.
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MeSH Terms
Conditioning, Operant / drug effects*
Macaca mulatta
Reinforcement (Psychology)
Tetrahydrocannabinol / pharmacology*
Time Factors
Grant Support
IAG 224-83-0005/AG/NIA NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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