| Acute effects of chlorogenic acid on nitric oxide status, endothelial function and blood pressure in healthy volunteers: a randomised trial. | |
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MedLine Citation:
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PMID: 22900702 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide. Our aim was to investigate the acute effects of chlorogenic acid, an important dietary phenolic acid present in coffee (400 mg, equivalent to 2 cups of coffee), on nitric oxide status, endothelial function and blood pressure. Healthy men and women (n=23) were recruited to a randomised, double-blind, placebo-controlled, cross-over trial. Chlorogenic acid resulted in significantly higher plasma concentrations of chlorogenic acid (P<0.001). Relative to control, mean post-treatment systolic blood pressure (-2.41 mm Hg, 95% CI: -0.03, -4.78; P=0.05) and diastolic blood pressure (-1.53 mm Hg, 95% CI: -0.05, -3.01; P=0.04) were significantly lower with chlorogenic acid. Markers of nitric oxide status (P>0.10) and the measure of endothelial function (P=0.60) were not significantly influenced. Chlorogenic acid can lower blood pressure acutely; an effect which if sustained would benefit cardiovascular health. |
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Authors:
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Aidilla Mubarak; Catherine P Bondonno; Alex H Liu; Michael James Considine; Lisa Rich; Emilie Mas; Kevin D Croft; Jonathan Hodgson |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-20 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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