Document Detail

Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial.
MedLine Citation:
PMID:  22900702     Owner:  NLM     Status:  MEDLINE    
There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide. Our aim was to investigate the acute effects of chlorogenic acid, an important dietary phenolic acid present in coffee (400 mg, equivalent to 2 cups of coffee), on nitric oxide status, endothelial function, and blood pressure. Healthy men and women (n = 23) were recruited to a randomized, double-blind, placebo-controlled, crossover trial. Chlorogenic acid resulted in significantly higher plasma concentrations of chlorogenic acid (P < 0.001). Relative to control, the mean post-treatment systolic blood pressure (-2.41 mmHg, 95% CI: -0.03, -4.78; P = 0.05) and diastolic blood pressure (-1.53 mmHg, 95% CI: -0.05, -3.01; P = 0.04) were significantly lower with chlorogenic acid. Markers of nitric oxide status (P > 0.10) and the measure of endothelial function (P = 0.60) were not significantly influenced. Chlorogenic acid can lower blood pressure acutely, an effect that, if sustained, would benefit cardiovascular health.
Aidilla Mubarak; Catherine P Bondonno; Alex H Liu; Michael J Considine; Lisa Rich; Emilie Mas; Kevin D Croft; Jonathan M Hodgson
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-09-04
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  60     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-12     Completed Date:  2013-01-24     Revised Date:  2013-12-10    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9130-6     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Chlorogenic Acid / administration & dosage*,  blood
Coffee / chemistry
Endothelium, Vascular / drug effects,  physiology*
Healthy Volunteers
Nitric Oxide / metabolism*
Reg. No./Substance:
0/Coffee; 318ADP12RI/Chlorogenic Acid; 31C4KY9ESH/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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