Document Detail

Acute effects of chewable nifedipine on hemodynamic responses to upright exercise in patients with prior myocardial infarction and effort angina.
MedLine Citation:
PMID:  6848334     Owner:  NLM     Status:  MEDLINE    
To evaluate the hemodynamic effects of nifedipine on anginal patients during exercise in the upright position, a placebo (P) and 20 mg of nifedipine were administered in a double-blind random sequence to ten patients presenting with exertional angina and a healed myocardial infarction. All patients had previously undergone coronary angiography. The effects of nifedipine in the upright position at rest, at the anginal threshold, and at the maximal level of exercise were studied. Nifedipine decreased systemic vascular resistances in upright position and increased the cardiac index. It reduced the severity of angina and allowed a higher physical work capacity without anginal symptoms. The most important beneficial effect of nifedipine appears to be the reduction in afterload, but an improvement of left ventricular function cannot be ruled out.
S Marra; V Paolillo; G Baduini; F Spadaccini; P F Angelino
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Chest     Volume:  83     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Angina Pectoris / drug therapy*,  physiopathology
Cardiac Output / drug effects
Exercise Test
Heart Catheterization
Hemodynamics / drug effects*
Middle Aged
Myocardial Infarction / physiopathology
Nifedipine / administration & dosage*
Pyridines / administration & dosage*
Reg. No./Substance:
0/Pyridines; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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