Document Detail

Acute effects of changing plasma osmolality and colloid oncotic pressure on the formation of brain edema after cryogenic injury.
MedLine Citation:
PMID:  2716975     Owner:  NLM     Status:  MEDLINE    
The cerebral effects of alterations in plasma osmolality (Osm) and colloid oncotic pressure (COP) were examined in normocarbic, normothermic, pentobarbital-anesthetized rabbits that had been subjected to cryogenic brain injury. Monitored variables in all animals included mean arterial, right atrial, and intracranial pressures (MAP, CVP, and ICP), electroencephalographic (EEG) recordings, and cerebral blood flow (CBF). When surgical preparation was complete, a left parietal lesion was produced with liquid nitrogen. Group 1 (control, n = 8) animals subsequently received only maintenance fluids [lactated Ringer's solution (LR)]. One hour after injury, 3 other groups of animals underwent 45 minutes of plasmapheresis, carried out by arterial phlebotomy (packed red cells returned), with separated plasma being replaced by one of three fluids given in amounts sufficient to maintain MAP and CVP at baseline values. The three fluids were 1) 6% hetastarch in hypo-osmotic LR [Group 2 (Hypo-Osm), n = 6; COP = 21 mm Hg, Osm = 130 mOsm/kg]; 2) iso-osmotic LR [Group 3 (Hypo-COP), n = 8; COP = 0; Osm = 305]; and 3) 6% hetastarch in iso-osmotic LR [Group 4 (Iso-Osm/COP), n = 8; COP = 21, Osm = 310]. The animals were killed by exsanguination 25 minutes after completion of plasmapheresis. The brain was removed, the hemispheres separated, weighed, and sliced, and the specific gravities (SpGr) of the regional tissue determined. There were no differences in MAP, CVP, regional CBF, or EEG activity among the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
R Kaieda; M M Todd; L N Cook; D S Warner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurosurgery     Volume:  24     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-19     Completed Date:  1989-06-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  671-8     Citation Subset:  IM    
Department of Anesthesia, College of Medicine, University of Iowa, Iowa City.
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MeSH Terms
Brain Edema / physiopathology*
Brain Injuries / etiology,  physiopathology*
Cold Temperature / adverse effects
Intracranial Pressure
Osmolar Concentration
Plasma Volume*
Water-Electrolyte Balance*
Grant Support
Reg. No./Substance:

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