Document Detail


Acute effects of carprofen and meloxicam on canine gastrointestinal permeability and mucosal absorptive capacity.
MedLine Citation:
PMID:  17939543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed to dogs for their analgesic, antipyretic, and anti-inflammatory properties. Their beneficial actions can be offset by gastrointestinal (GI) toxicosis. Endoscopy has traditionally been employed to detect GI lesions, but alterations in GI permeability precede the development of mucosal damage. HYPOTHESIS: Carprofen and meloxicam alter GI permeability and mucosal absorptive capacity of dogs. ANIMALS: Twenty adult dogs treated with an NSAID for >7 days were evaluated by permeability tests while receiving either carprofen (10 dogs) or meloxicam (10 dogs). METHODS: Prospective, longitudinal observational study. A 6-sugar permeability test (sucrose, lactulose, rhamnose, 3-O-methyl-D-glucose, D-xylose, and sucralose) was performed on the day before NSAID treatment, and after 3 and 8 days of treatment. RESULTS: There were no significant differences in the urinary recovery ratios of lactulose: rhamnose, D-xylose: 3-O-methyl-D-glucose, or sucralose recovery within either group at any time during the study. Sucrose permeability in the meloxicam group did not alter significantly over time. However, sucrose permeability in the carprofen group decreased significantly by day 3 (P = .049) and increased again by day 8 (P = .049), to a level that was not significantly different to permeability before treatment (P = .695). CONCLUSIONS AND CLINICAL IMPORTANCE: The absence of increased GI permeability and diminished mucosal absorptive capacity in this group of dogs does not support the development of acute GI toxicosis during treatment with either meloxicam or carprofen.
Authors:
Melanie Craven; Marge L Chandler; Jörg M Steiner; Ashkan Farhadi; Elizabeth Welsh; Kathryn Pratschke; Darren J Shaw; David A Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  21     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2007 Sep-Oct
Date Detail:
Created Date:  2007-10-17     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  917-23     Citation Subset:  IM    
Affiliation:
Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK. mdc57@cornell.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Carbazoles / pharmacology*
Carbohydrates / pharmacokinetics,  urine
Dogs / metabolism*,  urine
Female
Intestinal Absorption / drug effects
Intestinal Mucosa / drug effects*
Longitudinal Studies
Male
Permeability / drug effects
Prospective Studies
Statistics, Nonparametric
Thiazines / pharmacology*
Thiazoles / pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Carbazoles; 0/Carbohydrates; 0/Thiazines; 0/Thiazoles; 52263-47-5/carprofen; 71125-38-7/meloxicam

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