| Acute effects of caffeine ingestion at rest in humans with impaired epinephrine responses. | |
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MedLine Citation:
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PMID: 8964766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Caffeine ingestion has been demonstrated to increase circulating epinephrine (Epi) and norepinephrine (NE), elevate free fatty acids (FFAs), and alter heart rate, blood pressure (BP), and ventilation in humans. Whether these physiological responses are a result of caffeine acting through direct stimulation of specific tissues via adenosine receptors or secondary to Epi increases is not known. In the present experiment, six tetraplegics (level of spinal cord lesions C4-C6) were tested at rest for 3 h to investigate the effects of 6 mg/kg caffeine in capsule form on subjects with impaired Epi responses. Ventilatory, cardiovascular, metabolic, and hormonal data were collected every 15-20 min after caffeine ingestion. There were no significant (P > 0.05) increases in plasma Epi after caffeine ingestion [0.19 +/- 0.04 (SE) nM (preingestion); 0.20 +/- 0.04 nM (80 min postingestion)] or in plasma NE [0.53 +/- 0.16 nM (preingestion); 0.49 +/- 0.09 nM (80 min postingestion; P > 0.05)]. However, significant increases were found in serum FFAs [0.53 +/- 0.08 nM (preingestion); 1.03 +/- 0.20 mM (40 min postingestion; P < 0.05] and in glycerol. These concentrations remained elevated throughout the experiment. BP increased in the first hour postingestion. These data demonstrate that caffeine in physiological doses directly stimulates specific tissues, i.e., adipose and peripheral vascular tissue, and these effects are not secondary to increases in Epi after caffeine ingestion. |
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Authors:
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M Van Soeren; T Mohr; M Kjaer; T E Graham |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 80 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-12-03 Completed Date: 1996-12-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 999-1005 Citation Subset: IM |
Affiliation:
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Faculty of Nursing, Health Sciences Centre, University of Western Ontario, London, Canada. mvansoer@julian.uwo.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / metabolism Caffeine / pharmacology* Energy Metabolism / drug effects* Epinephrine / blood* Fatty Acids, Nonesterified / blood Humans Insulin / blood Male Time Factors Xanthines / blood* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Xanthines; 11061-68-0/Insulin; 28109-92-4/methylxanthine; 51-43-4/Epinephrine; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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