Document Detail

Acute effects of cadmium on delayed-type hypersensitivity in mice.
MedLine Citation:
PMID:  6460128     Owner:  NLM     Status:  MEDLINE    
A single exposure of mice to cadmium resulted in suppression of the induction of primary delayed-type hypersensitivity (DTH) responses as well as memory T-cell and suppressor T-cell activities, augmenting and inhibiting DTH respectively. Furthermore, cadmium suppressed the expression of already established DTH, in immune mice, even though DTH-effector T cells in the spleen of immune mice were not affected by cadmium injection. Such suppressive effects were demonstrated when cadmium was administered within 2 days before immunization or elicitation for DTH. Cadmium caused also within 2 days in mice thymic involution and splenomegaly. These results indicate that cadmium inhibits not only the generation of certain populations of T lymphocytes for DTH but also some mechanisms in the host involved in the expression of DTH.
A Kojima; S I Tamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of medical science & biology     Volume:  34     ISSN:  0021-5112     ISO Abbreviation:  Jpn. J. Med. Sci. Biol.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1982-04-12     Completed Date:  1982-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0243706     Medline TA:  Jpn J Med Sci Biol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  281-91     Citation Subset:  IM    
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MeSH Terms
Body Weight / drug effects
Cadmium Poisoning / immunology*
Hypersensitivity, Delayed / immunology*
Immunity, Cellular / drug effects
Organ Size / drug effects
Spleen / drug effects
T-Lymphocytes / immunology
T-Lymphocytes, Regulatory / immunology
Thymus Gland / drug effects
Reg. No./Substance:

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