| Acute effects of cadmium on delayed-type hypersensitivity in mice. | |
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MedLine Citation:
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PMID: 6460128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A single exposure of mice to cadmium resulted in suppression of the induction of primary delayed-type hypersensitivity (DTH) responses as well as memory T-cell and suppressor T-cell activities, augmenting and inhibiting DTH respectively. Furthermore, cadmium suppressed the expression of already established DTH, in immune mice, even though DTH-effector T cells in the spleen of immune mice were not affected by cadmium injection. Such suppressive effects were demonstrated when cadmium was administered within 2 days before immunization or elicitation for DTH. Cadmium caused also within 2 days in mice thymic involution and splenomegaly. These results indicate that cadmium inhibits not only the generation of certain populations of T lymphocytes for DTH but also some mechanisms in the host involved in the expression of DTH. |
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Authors:
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A Kojima; S I Tamura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese journal of medical science & biology Volume: 34 ISSN: 0021-5112 ISO Abbreviation: Jpn. J. Med. Sci. Biol. Publication Date: 1981 Oct |
Date Detail:
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Created Date: 1982-04-12 Completed Date: 1982-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0243706 Medline TA: Jpn J Med Sci Biol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 281-91 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Cadmium Poisoning / immunology* Female Hypersensitivity, Delayed / immunology* Immunity, Cellular / drug effects Mice Organ Size / drug effects Ovalbumin Spleen / drug effects T-Lymphocytes / immunology T-Lymphocytes, Regulatory / immunology Thymus Gland / drug effects |
| Chemical | |
Reg. No./Substance:
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9006-59-1/Ovalbumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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