| Acute effects of aspartame on large neutral amino acids and monoamines in rat brain. | |
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MedLine Citation:
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PMID: 6835009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dipeptide aspartame (APM; aspartylphenylalanine methylester), an artificial sweetener, was studied in vivo for its ability to influence brain levels of the large neutral amino acids and the rates of hydroxylation of the aromatic amino acids. The administration by gavage of APM (200 mg/kg) caused large increments in blood and brain levels of phenylalanine and tyrosine by 60 minutes. Brain tryptophan level was occasionally reduced significantly, but the brain levels of the branched-chain amino acids were always unaffected. Smaller doses (50, 100 mg/kg) also raised blood and brain tyrosine and phenylalanine, but did not reduce brain tryptophan levels. At the highest dose (200 mg/kg), APM gavage caused an insignificant increase in dopa accumulation (after NSD-1015), and a modest reduction in 5-hydroxytryptophan accumulation. No changes in the brain levels of serotonin, 5-hydroxyindoleacetic acid, dopamine, dihydroxyphenylacetic acid, homovanillic acid, or norepinephrine were produced by APM administration (200 mg/kg). These results thus indicate that APM, even when administered in amounts that cause large increments in brain tyrosine and phenylalanine, produce minimal effects on the rates of formation of monoamine transmitters. |
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Authors:
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J D Fernstrom; M H Fernstrom; M A Gillis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 32 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1983 Apr |
Date Detail:
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Created Date: 1983-05-05 Completed Date: 1983-05-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1651-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Amino Acids, Branched-Chain / metabolism Animals Aspartame / pharmacology* Brain / drug effects, metabolism* Catecholamines / metabolism* Dipeptides / pharmacology* Male Phenylalanine / metabolism Rats Rats, Inbred Strains Tryptophan / metabolism Tyrosine / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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MH00254/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Acids, Branched-Chain; 0/Catecholamines; 0/Dipeptides; 22839-47-0/Aspartame; 55520-40-6/Tyrosine; 63-91-2/Phenylalanine; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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