Document Detail

Acute effects of aspartame on large neutral amino acids and monoamines in rat brain.
MedLine Citation:
PMID:  6835009     Owner:  NLM     Status:  MEDLINE    
The dipeptide aspartame (APM; aspartylphenylalanine methylester), an artificial sweetener, was studied in vivo for its ability to influence brain levels of the large neutral amino acids and the rates of hydroxylation of the aromatic amino acids. The administration by gavage of APM (200 mg/kg) caused large increments in blood and brain levels of phenylalanine and tyrosine by 60 minutes. Brain tryptophan level was occasionally reduced significantly, but the brain levels of the branched-chain amino acids were always unaffected. Smaller doses (50, 100 mg/kg) also raised blood and brain tyrosine and phenylalanine, but did not reduce brain tryptophan levels. At the highest dose (200 mg/kg), APM gavage caused an insignificant increase in dopa accumulation (after NSD-1015), and a modest reduction in 5-hydroxytryptophan accumulation. No changes in the brain levels of serotonin, 5-hydroxyindoleacetic acid, dopamine, dihydroxyphenylacetic acid, homovanillic acid, or norepinephrine were produced by APM administration (200 mg/kg). These results thus indicate that APM, even when administered in amounts that cause large increments in brain tyrosine and phenylalanine, produce minimal effects on the rates of formation of monoamine transmitters.
J D Fernstrom; M H Fernstrom; M A Gillis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  32     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1651-8     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism*
Amino Acids, Branched-Chain / metabolism
Aspartame / pharmacology*
Brain / drug effects,  metabolism*
Catecholamines / metabolism*
Dipeptides / pharmacology*
Phenylalanine / metabolism
Rats, Inbred Strains
Tryptophan / metabolism
Tyrosine / metabolism
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Branched-Chain; 0/Catecholamines; 0/Dipeptides; 22839-47-0/Aspartame; 55520-40-6/Tyrosine; 63-91-2/Phenylalanine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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