Document Detail

Acute effect of tetrandrine pulmonary targeting microspheres on hypoxic pulmonary hypertension in rats.
MedLine Citation:
PMID:  11930667     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effect of tetrandrine (Tet) pulmonary targeting microspheres on hypoxic pulmonary hypertension and evaluate its selective action on pulmonary circulation. METHODS: Twenty rats were exposed to hypoxic conditions for 3 weeks. Ten rats were used as normoxic controls. We administered Tet pulmonary targeting microspheres to 10 hypoxic rats and Tet aqueous solution to 10 hypoxic rats and the 10 control rats. Mean pulmonary arterial pressure (mPAP) was measured by a right cardiac catheterization, and mean systemic blood pressure (mSBP) was measured by left femoral catheterization. RESULTS: Rats exposed to hypoxia developed pulmonary hypertension. The decrease in mPAP in rats treated with Tet pulmonary targeting microspheres was significantly greater than that in rats receiving Tet aqueous solution (P < 0.05), and the effects were longer with Tet pulmonary targeting microspheres. Moreover, Tet pulmonary targeting microspheres, unlike Tet aqueous solution, did not decrease mSBP. CONCLUSION: Tet pulmonary targeting microspheres were more effective than Tet aqueous solution treating hypoxic pulmonary hypertension and acted selectively on the pulmonary circulation.
Deyun Cheng; Wenbin Chen; Xiaoneng Mo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  115     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-04-04     Completed Date:  2002-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  81-3     Citation Subset:  IM    
Department of Internal Medicine, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, China.
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MeSH Terms
Alkaloids / administration & dosage*
Anoxia / physiopathology
Blood Pressure / drug effects
Hypertension, Pulmonary / drug therapy*
Lung / drug effects
Pulmonary Artery / drug effects,  physiology
Rats, Wistar
Reg. No./Substance:
0/Alkaloids; 0/Benzylisoquinolines; 518-34-3/tetrandrine

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