Document Detail

Acute effect of systemic aspirin on gastric mucosa in man.
MedLine Citation:
PMID:  7353465     Owner:  NLM     Status:  MEDLINE    
Aspirin was administered intravenously to study its effect upon gastric mucosa at high blood levels in the therapeutic range for rheumatic diseases. Five healthy volunteers were studied twice each with intravenous aspirin (3 g over 2 hr) and isotonic saline infusion as control. In one study, gastric potential difference was measured; in the other, coded gastric biopsies were taken sequentially prior to infusion, and at the end of infusion. Duplicate biopsies were taken for light and scanning electron microscopy. Mean potential difference at the end of the intravenous aspirin infusions was -47.7 +/- 1.4 mV, compared with saline, -51.1 +/- 2.5 mV (P greater than 0.05). The percentage of cells damaged after 2 hr intravenous infusion of aspirin (3.2 +/- 0.4%) was not significantly different from that after intravenous saline (2.6 +/- 0.3%). In contrast to oral aspirin, acute administration of aspirin parenterally does not produce detectable histological damage in man, nor does it significantly alter gastric mucosal potential difference. We conclude that high blood levels of circulating salicylate do not acutely damage gastric mucosa. Thus, histologic gastric mucosal damage produced acutely after single oral doses of aspirin are due to its topical, rather than systemic, action.
K J Ivey; D B Paone; W J Krause
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  25     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-04-25     Completed Date:  1980-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-9     Citation Subset:  AIM; IM    
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MeSH Terms
Aspirin / administration & dosage,  adverse effects*
Gastric Mucosa / drug effects,  pathology*,  ultrastructure
Infusions, Parenteral
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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