| Acute effect of metformin on exercise capacity in active males. | |
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MedLine Citation:
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PMID: 17970761 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Physical activity and metformin are often used concomitantly in the treatment of diabetes, even though little is known about possible interactions between these treatment modalities. This study was designed to examine the acute effect of metformin on oxygen consumption and lactate concentration during exercise. METHODS: Eleven healthy, active men [mean +/- s.d.: age = 29.9 +/- 3.7 years; body mass index = 25.2 +/- 2.8 kg/m2; maximal oxygen consumption (VO2max) = 53.5 +/- 8.9 ml/kg/min] completed a randomized, double-blind, placebo-controlled, crossover study. The testing protocol consisted of a standardized breakfast with metformin (1000 mg) or placebo. Three hours after breakfast, participants underwent a graded maximal exercise test on a cycle ergometer. Approximately 30 min after this exercise test, participants cycled continuously at an intensity below their ventilatory threshold for 45 min (mean exercise intensity = 69 +/- 5.5% of VO2max). RESULTS: During the graded exercise test, average oxygen consumption was higher for the metformin condition (2.9 vs. 2.8 l/min, p = 0.04); however, there was no treatment effect on VO2max or ventilatory threshold. During continuous exercise, lactate was lower for the metformin condition (4.7 vs. 5.4 mmol/l, p = 0.05). Following a standardized lunch, glucose concentrations were lower in the metformin compared with the placebo condition (5.8 vs. 6.4 mmol/l, p = 0.04). CONCLUSION: A single dose of metformin does not acutely influence maximal oxygen consumption or ventilatory threshold in healthy active males. The lower lactate concentration observed during continuous exercise with metformin was an unexpected finding considering that, in the resting state, metformin has been previously associated with a modest increase in lactate concentrations. |
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Authors:
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S T Johnson; C Robert; G J Bell; R C Bell; R Z Lewanczuk; N G Boulé |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-10-26 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: 10 ISSN: 1463-1326 ISO Abbreviation: Diabetes Obes Metab Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-21 Completed Date: 2009-05-14 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: England |
Other Details:
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Languages: eng Pagination: 747-54 Citation Subset: IM |
Affiliation:
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Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / drug effects*, metabolism Cross-Over Studies Double-Blind Method Exercise Test Humans Hypoglycemic Agents / administration & dosage* Lactates / blood* Male Metformin / administration & dosage* Oxygen Consumption / drug effects*, physiology Postprandial Period |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 0/Lactates; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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