| Acute effect of a high nitrate diet on brain perfusion in older adults. | |
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MedLine Citation:
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PMID: 20951824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Poor blood flow and hypoxia/ischemia contribute to many disease states and may also be a factor in the decline of physical and cognitive function in aging. Nitrite has been discovered to be a vasodilator that is preferentially harnessed in hypoxia. Thus, both infused and inhaled nitrite are being studied as therapeutic agents for a variety of diseases. In addition, nitrite derived from nitrate in the diet has been shown to decrease blood pressure and improve exercise performance. Thus, dietary nitrate may also be important when increased blood flow in hypoxic or ischemic areas is indicated. These conditions could include age-associated dementia and cognitive decline. The goal of this study was to determine if dietary nitrate would increase cerebral blood flow in older adults. METHODS AND RESULTS: In this investigation we administered a high vs. low nitrate diet to older adults (74.7±6.9 years) and measured cerebral perfusion using arterial spin labeling magnetic resonance imaging. We found that the high nitrate diet did not alter global cerebral perfusion, but did lead to increased regional cerebral perfusion in frontal lobe white matter, especially between the dorsolateral prefrontal cortex and anterior cingulate cortex. CONCLUSION: These results suggest that dietary nitrate may be useful in improving regional brain perfusion in older adults in critical brain areas known to be involved in executive functioning. |
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Authors:
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Tennille D Presley; Ashley R Morgan; Erika Bechtold; William Clodfelter; Robin W Dove; Janine M Jennings; Robert A Kraft; S Bruce King; Paul J Laurienti; W Jack Rejeski; Jonathan H Burdette; Daniel B Kim-Shapiro; Gary D Miller |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-15 |
Journal Detail:
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Title: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society Volume: 24 ISSN: 1089-8611 ISO Abbreviation: Nitric Oxide Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-10 Completed Date: 2011-05-24 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 9709307 Medline TA: Nitric Oxide Country: United States |
Other Details:
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Languages: eng Pagination: 34-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Physics, Wake Forest University, Winston-Salem, NC 27109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aged, 80 and over Analysis of Variance Brain / blood supply* Dietary Supplements Humans Magnetic Resonance Imaging Nitrates / administration & dosage*, blood Nitrites / blood* Regional Blood Flow / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL058091/HL/NHLBI NIH HHS; HL62198/HL/NHLBI NIH HHS; R01 HL058091-06/HL/NHLBI NIH HHS; R01 HL062198-01A2/HL/NHLBI NIH HHS; R37 HL058091-15/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 0/Nitrites |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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