Document Detail


Acute effect of haemodialysis on serum markers of myocardial damage.
MedLine Citation:
PMID:  12137438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac markers are more likely to be elevated in dialysis patients than in patients with renal failure not on dialysis. In this study, 31 patients (20 males, 11 females) undergoing chronic haemodialysis were enrolled. The effect of haemodialysis on cardiac troponin T (cTnT), I (cTnI), creatine kinase MB (CKMB) mass, CKMB activity and myoglobin assays was assessed by comparing pre- and post-haemodialysis determinations. After correcting for haemoconcentration, significant differences were observed (mean +/- SEM, pre- vs post-dialysis) for myoglobin (178.9 +/- 19.3 vs 225.0 +/- 28.4 ng/ml; p=0.006) for cTnT (0.111 +/- 0.028 vs 0.148 +/- 0.037 ng/ml; p=0.004), for CKMB mass (2.75 +/- 0.37 vs 2.59 +/- 0.37 ng/ml; p=0.000) and CKMB activity (14.8 +/- 0.9 vs 13.1 +/- 0.9 U/l; p=0.000) assays. Our study questions the reliability of cardiac markers in dialysis patients and suggests that the clinical threshold value and diagnostic efficiency of each assay needs to be validated. Although these differences exceeded clinical threshold values in only a few patients, serum markers of myocardial damage in dialysis patients should be interpreted with caution.
Authors:
M Tarakçioglu; Ab Erbagci; M Cekmen; C Usalan; H Ciçek; J Ozaslan; C Camci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical practice     Volume:  56     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-24     Completed Date:  2002-09-13     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  328-32     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Medicine, Gaziantep University, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Cardiomyopathies / blood*,  etiology
Creatine Kinase / blood
Creatine Kinase, MB Form
Female
Humans
Isoenzymes / blood
Kidney Failure, Chronic / blood,  complications,  therapy*
Male
Middle Aged
Myoglobin / blood
Renal Dialysis / adverse effects*
Troponin I / blood
Troponin T / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Isoenzymes; 0/Myoglobin; 0/Troponin I; 0/Troponin T; EC 2.7.3.2/Creatine Kinase; EC 2.7.3.2/Creatine Kinase, MB Form

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