| Acute effect of haemodialysis on serum markers of myocardial damage. | |
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MedLine Citation:
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PMID: 12137438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac markers are more likely to be elevated in dialysis patients than in patients with renal failure not on dialysis. In this study, 31 patients (20 males, 11 females) undergoing chronic haemodialysis were enrolled. The effect of haemodialysis on cardiac troponin T (cTnT), I (cTnI), creatine kinase MB (CKMB) mass, CKMB activity and myoglobin assays was assessed by comparing pre- and post-haemodialysis determinations. After correcting for haemoconcentration, significant differences were observed (mean +/- SEM, pre- vs post-dialysis) for myoglobin (178.9 +/- 19.3 vs 225.0 +/- 28.4 ng/ml; p=0.006) for cTnT (0.111 +/- 0.028 vs 0.148 +/- 0.037 ng/ml; p=0.004), for CKMB mass (2.75 +/- 0.37 vs 2.59 +/- 0.37 ng/ml; p=0.000) and CKMB activity (14.8 +/- 0.9 vs 13.1 +/- 0.9 U/l; p=0.000) assays. Our study questions the reliability of cardiac markers in dialysis patients and suggests that the clinical threshold value and diagnostic efficiency of each assay needs to be validated. Although these differences exceeded clinical threshold values in only a few patients, serum markers of myocardial damage in dialysis patients should be interpreted with caution. |
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Authors:
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M Tarakçioglu; Ab Erbagci; M Cekmen; C Usalan; H Ciçek; J Ozaslan; C Camci |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of clinical practice Volume: 56 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-24 Completed Date: 2002-09-13 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 328-32 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Medicine, Gaziantep University, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Cardiomyopathies / blood*, etiology Creatine Kinase / blood Creatine Kinase, MB Form Female Humans Isoenzymes / blood Kidney Failure, Chronic / blood, complications, therapy* Male Middle Aged Myoglobin / blood Renal Dialysis / adverse effects* Troponin I / blood Troponin T / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Isoenzymes; 0/Myoglobin; 0/Troponin I; 0/Troponin T; EC 2.7.3.2/Creatine Kinase; EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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