Document Detail

Acute effect of fentanyl on haemodynamics and myocardial carbohydrate utilization and phosphate release during ischaemia.
MedLine Citation:
PMID:  518794     Owner:  NLM     Status:  MEDLINE    
The effect of fentanyl 25 micrograms/kg body weight i.v. on left ventricular haemodynamics, myocardial carbohydrate utilization and phosphate release during ischaemia in dogs was investigated. A reproducible degree of ischaemia could be obtained by partial occlusion (stenosis) of the interventricular artery, using an inflatable cuff. Inducing stenosis twice made it possible to use the animal as its own control. Arterio-local venous differences of glucose increased during ischaemia and lactate and inorganic phosphate were released from the ischaemic myocardium. Fentanyl administered before the second stenosis reduced heart rate and, to a lesser extent, mean aortic pressure and left ventricular dP/dt max. The release of lactate and inorganic phosphate was diminished during the period of ischaemia. These findings suggest that fentanyl prevents excessive breakdown of energy-rich phosphates and high anaerobic production rate of lactate by decreasing the energy demand of the ischaemic myocardium.
G J van der Vusse; H van Belle; W van Gerven; R Kruger; R S Reneman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  51     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  927-35     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / metabolism
Coronary Disease / metabolism*,  physiopathology
Fentanyl / pharmacology*
Heart / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Lactates / blood
Myocardium / metabolism*
Phosphates / blood*
Reg. No./Substance:
0/Blood Glucose; 0/Lactates; 0/Phosphates; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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