Document Detail


Acute effect of atorvastatin on coronary circulation measured by transthoracic Doppler echocardiography in patients without coronary artery disease by angiography.
MedLine Citation:
PMID:  15979441     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-two patients were randomly assigned to treatment with placebo or atorvastatin. The time-averaged peak diastolic velocity (APDV) of the left anterior descending artery without stenosis was measured by transthoracic Doppler echocardiography at rest and under hyperemic conditions before and 1 hour after treatment. APDV increased significantly in the atorvastatin group, at rest and under hyperemic conditions, and coronary flow velocity reserve also increased in the atorvastatin group compared with patients given placebo. Atorvastatin improved the blood flow velocity of the normal coronary artery <1 hour after administration in patients without coronary artery disease by angiography.
Authors:
Toshihide Hinoi; Shusuke Matsuo; Futoshi Tadehara; Shuji Tsujiyama; Michio Yamakido
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  96     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-27     Completed Date:  2005-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, Kure Kyosai Hospital, Hiroshima, Japan. t-hinoi@kure-kyosai.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Anticholesteremic Agents / administration & dosage,  pharmacology*,  therapeutic use
Coronary Angiography
Coronary Circulation / drug effects*
Echocardiography, Doppler
Female
Heptanoic Acids / administration & dosage,  pharmacology*,  therapeutic use
Humans
Male
Middle Aged
Placebos
Pyrroles / administration & dosage,  pharmacology*,  therapeutic use
Regional Blood Flow
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Heptanoic Acids; 0/Placebos; 0/Pyrroles; 110862-48-1/atorvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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