Document Detail

Acute effect of ambient ozone on heart rate variability in healthy elderly subjects.
MedLine Citation:
PMID:  21522190     Owner:  NLM     Status:  MEDLINE    
Acute ambient ozone (O(3)) exposure is associated with the increased mortality and morbidity of cardiovascular diseases. The dysfunction of cardiac autonomic nervous system (ANS), indicated by the disturbed heart rate variability (HRV), may be the most important underlying mechanism. Previous studies reported the heterogeneous associations between O(3) within several hours' exposure and HRV on general elderly subjects, in which poor surrogate of exposure evaluation and different health status of the subjects may be responsible for the heterogeneous associations. No studies were found focusing on the O(3)-mediated HRV effects within several minutes' exposure on healthy older subjects until recently. We measured the real-time 5-min ambient O(3) concentration and HRV frequency indices in 20 healthy elderly subjects in two surveys, with the 1st and 2nd survey in summer and winter, respectively. Mixed-linear model was used to evaluate the associations between the ambient 5-min average O(3) and concurrent 5-min HRV frequency indices measured during the outdoor period. After adjusting the co-pollutants (ambient PM(2.5) and nitrogen oxides concentrations) and subject characteristics, high frequency (HF) changed -4.87% (95% CI -8.62 to -0.97%) per 10 ppb increment of O(3), whereas decreased low frequency (LF) and increased LFHFR were found to be marginally associated with the elevated O(3) (P values were 0.092 and 0.069). We concluded that the ambient O(3) exert transient decrease effects on HRV, which may induce acute cardiac events.
Xiaofeng Jia; Xiaoming Song; Masayuki Shima; Kenji Tamura; Furong Deng; Xinbiao Guo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-27
Journal Detail:
Title:  Journal of exposure science & environmental epidemiology     Volume:  21     ISSN:  1559-064X     ISO Abbreviation:  J Expo Sci Environ Epidemiol     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-08-24     Completed Date:  2011-12-09     Revised Date:  2012-03-26    
Medline Journal Info:
Nlm Unique ID:  101262796     Medline TA:  J Expo Sci Environ Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  541-7     Citation Subset:  IM    
Peking University School of Public Health, Beijing, China.
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MeSH Terms
Air Pollutants / toxicity*
Blood Pressure / drug effects
Body Mass Index
Case-Control Studies
Data Collection
Heart Conduction System / drug effects,  metabolism,  pathology
Heart Rate / drug effects*
Lipids / blood
Middle Aged
Nitrogen Oxides / toxicity
Ozone / toxicity*
Particle Size
Particulate Matter / toxicity*
Time Factors
Reg. No./Substance:
0/Air Pollutants; 0/Lipids; 0/Nitrogen Oxides; 0/Particulate Matter; 10028-15-6/Ozone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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