| Acute effect of ambient ozone on heart rate variability in healthy elderly subjects. | |
MedLine Citation:
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PMID: 21522190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute ambient ozone (O(3)) exposure is associated with the increased mortality and morbidity of cardiovascular diseases. The dysfunction of cardiac autonomic nervous system (ANS), indicated by the disturbed heart rate variability (HRV), may be the most important underlying mechanism. Previous studies reported the heterogeneous associations between O(3) within several hours' exposure and HRV on general elderly subjects, in which poor surrogate of exposure evaluation and different health status of the subjects may be responsible for the heterogeneous associations. No studies were found focusing on the O(3)-mediated HRV effects within several minutes' exposure on healthy older subjects until recently. We measured the real-time 5-min ambient O(3) concentration and HRV frequency indices in 20 healthy elderly subjects in two surveys, with the 1st and 2nd survey in summer and winter, respectively. Mixed-linear model was used to evaluate the associations between the ambient 5-min average O(3) and concurrent 5-min HRV frequency indices measured during the outdoor period. After adjusting the co-pollutants (ambient PM(2.5) and nitrogen oxides concentrations) and subject characteristics, high frequency (HF) changed -4.87% (95% CI -8.62 to -0.97%) per 10 ppb increment of O(3), whereas decreased low frequency (LF) and increased LFHFR were found to be marginally associated with the elevated O(3) (P values were 0.092 and 0.069). We concluded that the ambient O(3) exert transient decrease effects on HRV, which may induce acute cardiac events. |
Authors:
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Xiaofeng Jia; Xiaoming Song; Masayuki Shima; Kenji Tamura; Furong Deng; Xinbiao Guo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-27 |
Journal Detail:
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Title: Journal of exposure science & environmental epidemiology Volume: 21 ISSN: 1559-064X ISO Abbreviation: J Expo Sci Environ Epidemiol Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-08-24 Completed Date: 2011-12-09 Revised Date: 2012-03-26 |
Medline Journal Info:
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Nlm Unique ID: 101262796 Medline TA: J Expo Sci Environ Epidemiol Country: United States |
Other Details:
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Languages: eng Pagination: 541-7 Citation Subset: IM |
Affiliation:
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Peking University School of Public Health, Beijing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Air Pollutants / toxicity* Blood Pressure / drug effects Body Mass Index Case-Control Studies Data Collection Female Heart Conduction System / drug effects, metabolism, pathology Heart Rate / drug effects* Humans Lipids / blood Male Middle Aged Nitrogen Oxides / toxicity Ozone / toxicity* Particle Size Particulate Matter / toxicity* Seasons Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Lipids; 0/Nitrogen Oxides; 0/Particulate Matter; 10028-15-6/Ozone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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