| Acute drug-associated rhabdomyolysis: an examination of its diverse renal manifestations and complications. | |
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MedLine Citation:
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PMID: 7435519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty patients with drug associated acute nontraumatic rhabdomyolysis were evaluated. Acute renal failure, oliguric (ORF) in ten and nonoliguric (NORF) in another ten patients, was observed. The remaining ten patients did not develop renal failure (NRF). To identify factors that may have contributed to this clinical diversity, these three groups were compared. Data from 51 patients reported in the literature were also included in the analysis. The patients with ORF were slightly younger than patients with NORF. They had higher incidence of muscle swelling and higher serum potassium. ORF was more severe, lasted longer, and required more dialysis than NORF. The group of patients with renal failure had higher incidence of coma and more patients with very high muscle enzyme elevation than NRF patients. Hypercalcemia, a unique complication of rhabdomyolysis, was reported in 22 patients. It was not seen in patients without renal failure. There were no differences in age, incidence of coma, muscle swelling, and muscle enzyme between those who did and those who did not develop hypercalcemia. Sixteen patients with nerve entrapment had higher incidence of coma and muscle swelling than the rest of the patients. |
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Authors:
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P Cadnapaphornchai; S Taher; F D McDonald |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 280 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1980 Sep-Oct |
Date Detail:
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Created Date: 1981-01-29 Completed Date: 1981-01-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 66-72 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcoholism / complications Coma / chemically induced Creatinine / blood Female Humans Hypercalcemia / chemically induced Hypnotics and Sedatives / adverse effects Kidney Failure, Acute / chemically induced* Male Muscles / enzymology Muscular Diseases / chemically induced* Opioid-Related Disorders / complications Potassium / blood |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 60-27-5/Creatinine; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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