Document Detail


Acute drug-associated rhabdomyolysis: an examination of its diverse renal manifestations and complications.
MedLine Citation:
PMID:  7435519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty patients with drug associated acute nontraumatic rhabdomyolysis were evaluated. Acute renal failure, oliguric (ORF) in ten and nonoliguric (NORF) in another ten patients, was observed. The remaining ten patients did not develop renal failure (NRF). To identify factors that may have contributed to this clinical diversity, these three groups were compared. Data from 51 patients reported in the literature were also included in the analysis. The patients with ORF were slightly younger than patients with NORF. They had higher incidence of muscle swelling and higher serum potassium. ORF was more severe, lasted longer, and required more dialysis than NORF. The group of patients with renal failure had higher incidence of coma and more patients with very high muscle enzyme elevation than NRF patients. Hypercalcemia, a unique complication of rhabdomyolysis, was reported in 22 patients. It was not seen in patients without renal failure. There were no differences in age, incidence of coma, muscle swelling, and muscle enzyme between those who did and those who did not develop hypercalcemia. Sixteen patients with nerve entrapment had higher incidence of coma and muscle swelling than the rest of the patients.
Authors:
P Cadnapaphornchai; S Taher; F D McDonald
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  280     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:    1980 Sep-Oct
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  66-72     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcoholism / complications
Coma / chemically induced
Creatinine / blood
Female
Humans
Hypercalcemia / chemically induced
Hypnotics and Sedatives / adverse effects
Kidney Failure, Acute / chemically induced*
Male
Muscles / enzymology
Muscular Diseases / chemically induced*
Opioid-Related Disorders / complications
Potassium / blood
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 60-27-5/Creatinine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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