Document Detail

Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants.
MedLine Citation:
PMID:  20012022     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Schizophrenia is commonly associated with impairments in pre-attentive change detection, as represented by reduced mismatch negativity (MMN). While the neurochemical basis of MMN has been linked to N-methyl-D: -aspartic acid (NMDA) receptor function, the roles of the dopaminergic and/or the serotonergic systems are not fully explored in humans. OBJECTIVES: The aim of the present study was to investigate the effects of acutely depleting dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) alone or simultaneously by depleting their amino acid precursors on MMN in healthy participants. METHODS: Sixteen healthy male subjects participated in a double-blind, placebo-controlled, cross-over design in which each subject's duration MMN was assessed under four acute treatment conditions separated by a 5-day washout period: balanced amino acid control (no depletion), tyrosine/phenylalanine depletion (to reduce DA neurotransmission), tryptophan depletion (to reduce 5-HT neurotransmission) and tryptophan/tyrosine/phenylalanine depletion (to reduce DA and 5-HT neurotransmission simultaneously). RESULTS: Acute depletion of either DA and 5-HT alone or simultaneously had no effect on MMN. CONCLUSIONS: These findings suggest that modulation of the dopaminergic and serotonergic systems acutely does not lead to changes in MMN.
Sumie Leung; Rodney J Croft; Val?rie Guille; Kirsty Scholes; Barry V O'Neill; K Luan Phan; Pradeep J Nathan
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-12-10
Journal Detail:
Title:  Psychopharmacology     Volume:  208     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  233-44     Citation Subset:  IM    
Brain Sciences Institute, Faculty of Life and Social Sciences, Swinburne University of Technology, P.O. Box 218, John Street Hawthorn, 3122, Melbourne, VIC, Australia.
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MeSH Terms
Contingent Negative Variation*
Cross-Over Studies
Dopamine / deficiency*
Double-Blind Method
Neural Pathways / metabolism*
Phenylalanine / deficiency
Reaction Time
Serotonin / deficiency*
Time Factors
Tryptophan / deficiency
Tyrosine / deficiency
Young Adult
Reg. No./Substance:
50-67-9/Serotonin; 55520-40-6/Tyrosine; 63-91-2/Phenylalanine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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