| Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants. | |
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MedLine Citation:
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PMID: 20012022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE: Schizophrenia is commonly associated with impairments in pre-attentive change detection, as represented by reduced mismatch negativity (MMN). While the neurochemical basis of MMN has been linked to N-methyl-D: -aspartic acid (NMDA) receptor function, the roles of the dopaminergic and/or the serotonergic systems are not fully explored in humans. OBJECTIVES: The aim of the present study was to investigate the effects of acutely depleting dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) alone or simultaneously by depleting their amino acid precursors on MMN in healthy participants. METHODS: Sixteen healthy male subjects participated in a double-blind, placebo-controlled, cross-over design in which each subject's duration MMN was assessed under four acute treatment conditions separated by a 5-day washout period: balanced amino acid control (no depletion), tyrosine/phenylalanine depletion (to reduce DA neurotransmission), tryptophan depletion (to reduce 5-HT neurotransmission) and tryptophan/tyrosine/phenylalanine depletion (to reduce DA and 5-HT neurotransmission simultaneously). RESULTS: Acute depletion of either DA and 5-HT alone or simultaneously had no effect on MMN. CONCLUSIONS: These findings suggest that modulation of the dopaminergic and serotonergic systems acutely does not lead to changes in MMN. |
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Authors:
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Sumie Leung; Rodney J Croft; Val?rie Guille; Kirsty Scholes; Barry V O'Neill; K Luan Phan; Pradeep J Nathan |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2009-12-10 |
Journal Detail:
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Title: Psychopharmacology Volume: 208 ISSN: 1432-2072 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: Germany |
Other Details:
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Languages: eng Pagination: 233-44 Citation Subset: IM |
Affiliation:
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Brain Sciences Institute, Faculty of Life and Social Sciences, Swinburne University of Technology, P.O. Box 218, John Street Hawthorn, 3122, Melbourne, VIC, Australia. smleung@groupwise.swin.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contingent Negative Variation* Cross-Over Studies Dopamine / deficiency* Double-Blind Method Electroencephalography Humans Male Neural Pathways / metabolism* Phenylalanine / deficiency Reaction Time Serotonin / deficiency* Time Factors Tryptophan / deficiency Tyrosine / deficiency Young Adult |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 55520-40-6/Tyrosine; 63-91-2/Phenylalanine; 73-22-3/Tryptophan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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