Document Detail

Acute disseminated encephalomyelitis associated with Mycoplasma pneumoniae infection.
MedLine Citation:
PMID:  8992859     Owner:  NLM     Status:  MEDLINE    
An 8 year old girl with acute disseminated encephalomyelitis (ADEM) is described. Elevated serum antibody titers suggested recent Mycoplasma pneumoniae infection. T2-weighted image of magnetic resonance imaging (MRI) disclosed multiple lesions of high signal intensity in bilateral basal ganglia and thalami as well as in the white matter. Postcontrast T1-weighted image revealed an enhanced lesion in the deep white matter. She showed rapid clinical improvement in response to corticosteroid therapy. The lesions had disappeared completely on MRI performed 10 weeks after the onset. ADEM is believed to be a demyelinating disorder of probable autoimmune etiology. MRI findings in this case may support the hypothesis that the primary pathological event is vascular injury and demyelination occurs only as a secondary phenomenon.
K Yamamoto; M Takayanagi; Y Yoshihara; Y Murata; S Kato; M Otake; H Nakagawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  38     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-01-14     Completed Date:  1997-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  46-51     Citation Subset:  IM    
Department of Pediatrics, Sendai City Hospital, Japan.
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MeSH Terms
Basal Ganglia / pathology
Brain / pathology*
Contrast Media
Encephalomyelitis, Acute Disseminated / diagnosis,  etiology*
Follow-Up Studies
Gadolinium DTPA
Magnetic Resonance Imaging*
Nerve Fibers, Myelinated / pathology
Organometallic Compounds / diagnostic use
Pentetic Acid / analogs & derivatives,  diagnostic use
Pneumonia, Mycoplasma / complications*,  diagnosis
Thalamus / pathology
Reg. No./Substance:
0/Contrast Media; 0/Organometallic Compounds; 67-43-6/Pentetic Acid; 80529-93-7/Gadolinium DTPA

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