| Acute demyelinating optic neuritis: a review. | |
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MedLine Citation:
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PMID: 17981719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute demyelinating optic neuritis (ON) is a leading consideration in the differential diagnosis for young adults presenting with sudden onset of painful unilateral visual loss. Multiple sclerosis (MS) is believed to be the most common etiology for ON. Nearly 50% of MS patients will develop ON, and in 15-20% of cases, ON will be the initial manifestation of the illness. Conventional and emerging magnetic resonance imaging (MRI) techniques have provided greater insight into the pathophysiology of ON, and conventional MRI has also allowed clinicians to better estimate the future risk of MS. At 10 years after ON, patients with zero, one, or two or more brain lesions on T2-weighted MRI sequences demonstrated a 22%, 52%, and 56% risk of developing MS, respectively. Treatment with high dose intravenous methylprednisolone may accelerate visual recovery in patients with acute ON, but has little impact on long term visual outcome. Disease modifying therapies in patients with acute demyelinating ON should be considered as a treatment option at the time of initial presentation in those patients whose initial brain MRI shows demyelinating lesions as these therapies have been shown in to be effective at reducing the future risk of MS. |
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Authors:
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Steven David Brass; Robert Zivadinov; Rohit Bakshi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2008-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 13 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2008 |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2007-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 2376-90 Citation Subset: IM |
Affiliation:
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Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Partners Multiple Sclerosis Center, Boston, MA, USA. sbrass@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrophy Demyelinating Diseases / therapy Diffusion Female Humans Magnetic Resonance Imaging / methods Magnetics Optic Nerve / pathology* Optic Neuritis / diagnosis*, epidemiology, pathology* Placebos Prognosis Tomography, Optical Coherence / methods |
| Grant Support | |
ID/Acronym/Agency:
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1R01NS055083-01/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Placebos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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