| Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. | |
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MedLine Citation:
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PMID: 10694109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Creatine monohydrate (CrM) administration may enhance high intensity exercise performance and increase body mass, yet few studies have examined for potential adverse effects, and no studies have directly considered potential gender differences. PURPOSE: The purpose of this study was to examine the effect of acute creatine supplementation upon total and lean mass and to determine potential side effects in both men and women. METHODS: The effect of acute CrM (20 g x d(-1) x 5 d) administration upon systolic, diastolic, and mean BP, plasma creatinine, plasma CK activity, and body composition was examined in 15 men and 15 women in a randomized, double-blind experiment. Additionally, ischemic isometric handgrip strength was measured before and after CrM or placebo (PL). RESULTS: CrM did not affect blood pressure, plasma creatinine, estimated creatinine clearance, plasma CK activity, or handgrip strength (P > 0.05). In contrast, CrM significantly increased fat-free mass (FFM) and total body mass (P < 0.05) as compared with PL, with no changes in body fat. The observed mass changes were greater for men versus women. CONCLUSIONS: These findings suggest that acute CrM administration does not affect blood pressure, renal function, or plasma CK activity, but increases FFM. The effect of CrM upon FFM may be greater in men as compared with that in women. |
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Authors:
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S Mihic; J R MacDonald; S McKenzie; M A Tarnopolsky |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 32 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-03-15 Completed Date: 2000-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 291-6 Citation Subset: IM; S |
Affiliation:
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Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects* Body Composition* Creatine / administration & dosage, adverse effects, pharmacology* Creatinine / blood* Dietary Supplements* Double-Blind Method Exercise / physiology Female Hand Strength Humans Male Sex Factors |
| Chemical | |
Reg. No./Substance:
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57-00-1/Creatine; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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