Document Detail

Acute coronary syndromes in human immunodeficiency virus patients: a meta-analysis investigating adverse event rates and the role of antiretroviral therapy.
MedLine Citation:
PMID:  22187508     Owner:  NLM     Status:  MEDLINE    
AIMS: Highly active antiretroviral therapy (HAART) dramatically reduces human immunodeficiency virus (HIV)-associated morbidity and mortality, but adverse effects of HAART are becoming an increasing challenge, especially in the setting of acute coronary syndromes (ACS). We thus performed a comprehensive review of studies focusing on ACS in HIV patients.
METHODS AND RESULTS: MEDLINE/PubMed was systematically screened for studies reporting on ACS in HIV patients. Baseline, treatment, and outcome data were appraised and pooled with random-effect methods computing summary estimates [95% confidence intervals (CIs)]. A total of 11 studies including 2442 patients were identified, with a notably low prevalence of diabetes [10.86 (4.11, 17.60); 95% CI]. Rates of in-hospital death were 8.00% (2.8, 12.5; 95% CI), ascribable to cardiovascular events for 7.90% (2.43, 13.37; 95% CI), with 2.31% (0.60, 4.01; 95% CI) developing cardiogenic shock. At a median follow-up of 25.50 months (11.25, 42; 95% CI), no deaths were recorded, with an incidence of 9.42% of acute myocardial infarction (2.68, 16.17; 95% CI) and of 20.18% (9.84, 30.51; 95% CI) of percutaneous coronary revascularization. Moreover, pooled analysis of the studies reporting incidence of acute myocardial infarction in patients exposed to protease inhibitors showed an overall significant risk of 2.68 (odds ratio 1.89, 3.89; 95% CI).
CONCLUSION: Human immunodeficiency virus patients admitted for ACS face a substantial short-term risk of death and a significant long-term risk of coronary revascularization and myocardial infarction, especially if receiving protease inhibitors.
Fabrizio D'Ascenzo; Enrico Cerrato; Giuseppe Biondi-Zoccai; Claudio Moretti; Pierluigi Omedè; Filippo Sciuto; Mario Bollati; Maria Grazia Modena; Fiorenzo Gaita; Imad Sheiban
Related Documents :
19920028 - Prediction of cardiac resynchronization therapy response: value of calibrated integrate...
22325088 - Prognostic value of uric acid in patients with acute coronary syndromes.
22762928 - Early prediction of acute kidney injury in patients with acute myocardial injury.
19959118 - Effect of lateral wall scar on reverse remodeling with cardiac resynchronization therapy.
8590528 - Peripheral vascular complications following coronary interventional procedures.
22437128 - Left ventricular pseudoaneurysm demonstrated by 64-multislice computed tomography.
Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2011-12-20
Journal Detail:
Title:  European heart journal     Volume:  33     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-04     Completed Date:  2012-06-15     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  875-80     Citation Subset:  IM    
Division of Cardiology, University of Turin, S. Giovanni Battista 'Molinette' Hospital, Corso Bramante 88-90, Turin 10126, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Coronary Syndrome / chemically induced*
Angioplasty, Balloon, Coronary / statistics & numerical data
Anti-HIV Agents / adverse effects*
Epidemiologic Methods
HIV Infections / drug therapy*
HIV Protease Inhibitors / adverse effects
Middle Aged
Myocardial Infarction / chemically induced
Reg. No./Substance:
0/Anti-HIV Agents; 0/HIV Protease Inhibitors
Comment In:
Eur Heart J. 2012 Apr;33(7):813-5   [PMID:  22108832 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Complete loss of expression of the ANT1 gene causing cardiomyopathy and myopathy.
Next Document:  High-sensitivity C-reactive protein, statin therapy, and risks of atrial fibrillation: an explorator...