| Acute coronary syndromes: Virchow's triad revisited. | |
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MedLine Citation:
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PMID: 14517485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The acute coronary syndromes (ACS), which include unstable angina, non-ST-segment and ST-segment elevation acute myocardial infarction, all share common pathophysiology processes that are characterized by coronary plaque disruption with superimposed thrombus formation, leading to myocardial ischaemia. A greater understanding of these processes has enable us to correlate the abnormalities in arterial vessel wall substrates ('vessel abnormalities'), rheologic and biomechanical conditions ('abnormal flow'), and blood thrombogenicity ('abnormal blood constituents') to the contribution of coronary plaque disruption and subsequent thrombosis, with the basic concepts of Virchow's triad for thrombus formation (thrombogenesis) described about 150 years ago. This improved understanding has led to the identification of newer therapeutic targets and, hence, novel pharmacological agents targeting different components of Virchow's triad, particularly in altering thrombus formation and plaque vulnerability. |
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Authors:
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Kaeng W Lee; Gregory Y Lip |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 14 ISSN: 0957-5235 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-30 Completed Date: 2004-07-08 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 605-25 Citation Subset: IM |
Affiliation:
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Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Angina, Unstable / etiology, pathology Blood Cells / chemistry, physiology Coronary Circulation Coronary Disease / drug therapy, etiology*, pathology* Coronary Thrombosis / complications, etiology, pathology Endothelium, Vascular / chemistry, pathology Hematologic Agents / therapeutic use Humans Muscle, Smooth, Vascular / chemistry, pathology Myocardial Infarction / etiology, pathology Myocardial Ischemia / etiology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Hematologic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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