Document Detail

Acute coronary syndromes: Virchow's triad revisited.
MedLine Citation:
PMID:  14517485     Owner:  NLM     Status:  MEDLINE    
The acute coronary syndromes (ACS), which include unstable angina, non-ST-segment and ST-segment elevation acute myocardial infarction, all share common pathophysiology processes that are characterized by coronary plaque disruption with superimposed thrombus formation, leading to myocardial ischaemia. A greater understanding of these processes has enable us to correlate the abnormalities in arterial vessel wall substrates ('vessel abnormalities'), rheologic and biomechanical conditions ('abnormal flow'), and blood thrombogenicity ('abnormal blood constituents') to the contribution of coronary plaque disruption and subsequent thrombosis, with the basic concepts of Virchow's triad for thrombus formation (thrombogenesis) described about 150 years ago. This improved understanding has led to the identification of newer therapeutic targets and, hence, novel pharmacological agents targeting different components of Virchow's triad, particularly in altering thrombus formation and plaque vulnerability.
Kaeng W Lee; Gregory Y Lip
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  14     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-30     Completed Date:  2004-07-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  605-25     Citation Subset:  IM    
Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK.
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MeSH Terms
Acute Disease
Angina, Unstable / etiology,  pathology
Blood Cells / chemistry,  physiology
Coronary Circulation
Coronary Disease / drug therapy,  etiology*,  pathology*
Coronary Thrombosis / complications,  etiology,  pathology
Endothelium, Vascular / chemistry,  pathology
Hematologic Agents / therapeutic use
Muscle, Smooth, Vascular / chemistry,  pathology
Myocardial Infarction / etiology,  pathology
Myocardial Ischemia / etiology,  pathology
Reg. No./Substance:
0/Hematologic Agents

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