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Acute coronary syndrome secondary to clarithromycin: the first case and review of the literature.
MedLine Citation:
PMID:  25080953     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Kounis syndrome (KS) is characterized by concurrent acute coronary syndrome and allergic reaction, in which acute inflammatory mediators cause spasm and/or erosion and rupture of coronary atheromatous plaque. In this report, we remind clinicians to consider KS in patients who are subjected to allergenic substances and demonstrate acute chest pain. A 36-year-old woman had chest pain, severe dyspnea, hypotension, and symmetrical negative T waves on the anterior leads during electrocardiography approximately two hours after the use of clarithromycin. KS was considered as a possible diagnosis based on the presentation. Laboratory tests revealed an elevated level of troponin I, suggesting myocardial infarction, and an elevated level of serum tryptase level, suggesting an allergic reaction. The patient promptly underwent coronary angiography, which revealed only plaques in all main coronary arteries without any obstructive lesion. To the best of our knowledge, we report herein the first case in the literature describing an association between clarithromycin and KS.
Authors:
Murat Bilgin; Ahmet Akyel; Mehmet Doğan; Hamza Sunman; Ekrem Yeter
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir     Volume:  42     ISSN:  1016-5169     ISO Abbreviation:  Turk Kardiyol Dern Ars     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-8-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9426239     Medline TA:  Turk Kardiyol Dern Ars     Country:  -    
Other Details:
Languages:  ENG     Pagination:  461-463     Citation Subset:  -    
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