Document Detail


Acute coronary occlusion and reperfusion. Reliability of angiographic classification and grading.
MedLine Citation:
PMID:  3315585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
93 patients with acute myocardial infarction entered into a multicentre, randomised fibrinolytic therapy study underwent coronary angiography prior to treatment with intracoronary streptokinase or intravenous anisoylated plasminogen streptokinase activator complex (APSAC). Subsequent to administration of fibrinolytic therapy, coronary arteriography of the infarct-related artery was also performed at 15, 30, 45, 60, 75 and 90 minutes. Angiographically defined coronary perfusion was graded as follows: grade 0--no perfusion; grade 1--vessel penetration by contrast without perfusion; grade 2--partial perfusion with delayed flow and/or clearance; grade 3--normal flow and clearance. Two independent readers at separate sites reviewed all serial angiograms with consensus achieved with a third reader. Disagreement potentially affecting therapeutic outcome (grades 1 vs 2, 0 vs 2, 0 vs 3, and 1 vs 3) occurred for only 15 angiographic views. Evaluation of agreement by the K index demonstrated a reasonable level of agreement for all grades (K = 0.73). In order to assess the effect of angiographic classification and timing upon reperfusion percentage rates, 4 reperfusion criteria were applied to these serial angiograms: group A = grade 2 or 3 flow at 90 minutes; group B = grade 2 or 3 flow at any time; group C = grade 1, 2 or 3 flow at any time in patients with control grade 0 or 1 flow; group D = grade 1, 2 or 3 flow at any time in patients with only grade 0 flow at control. Percentage reperfusion varied widely depending upon reperfusion criteria: group A: streptokinase 49%, APSAC 44%; group B: streptokinase 70%, APSAC 50%; group C: streptokinase 86%, APSAC 67%; group D: streptokinase 79%, APSAC 59%.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S G Sorensen; R A Hackworthy; P G Fitzpatrick; W H Barry; R L Menlove; J L Anderson
Related Documents :
10344035 - Clinical profile of saruplase: angiographic findings.
3713255 - Serum, red blood cell and whole blood magnesium in patients with uncomplicated acute my...
1155475 - Bradycardia-hypotension syndrome in acute myocardial infarction. reappraisal of the ove...
15665255 - Magnesium deficiency in critical illness.
22075975 - Geranylgeranylacetone protects against myocardial ischemia and reperfusion injury by in...
9104895 - Further st elevation at reperfusion by direct percutaneous transluminal coronary angiop...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Drugs     Volume:  33 Suppl 3     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-07     Completed Date:  1988-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Affiliation:
LDS Hospital, University of Utah Medical Center, Salt Lake City.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anistreplase
Coronary Angiography*
Fibrinolytic Agents / therapeutic use
Humans
Infusions, Intra-Arterial
Injections, Intravenous
Myocardial Infarction / drug therapy,  radiography*
Plasminogen / therapeutic use
Random Allocation
Streptokinase / therapeutic use
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; 81669-57-0/Anistreplase; 9001-91-6/Plasminogen; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reperfusion in acute myocardial infarction. A multicentre randomised trial of early intracoronary st...
Next Document:  Evaluation of 2 intravenous thrombolytic agents (anisoylated plasminogen streptokinase activator com...