Document Detail

Acute congestive heart failure associated with a limited form of systemic sclerosis and primary biliary cirrhosis.
MedLine Citation:
PMID:  11201376     Owner:  NLM     Status:  MEDLINE    
This is the first case of a limited form of systemic sclerosis (ISSc) associated with acute congestive heart failure (CHF) and primary biliary cirrhosis (PBC). A 58-year-old woman with ISSc was admitted because of a sudden onset of CHF. The intravenous administration of nitroglycerine and furosemide ameliorated the symptoms of CHF within 24 hours. She had both anticentromere antibodies and anti-p25 doublet/triplet antibodies to intrahepatic microsomes. Thallium scintigraphy at rest demonstrated significant perfusion defects in both the anteroseptal and inferior myocardium. A coronary angiogram revealed normal coronary arteries and no vasospasm was provoked by the intracoronary administration of acetylcholine. The present case indicates that minute care should thus be taken for the prevention of acute CHF even in patients with a limited form of SSc when thallium perfusion defects are identified.
T Shinohara; H Yanai; T Hidaka; K Suzuki; F Ohsuzu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  40     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Internal Medicine I, National Defense Medical College, Tokorozawa, Saitama.
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MeSH Terms
Acute Disease
Antibody Specificity
Autoantibodies / blood,  immunology
Autoimmune Diseases / complications*,  diagnosis
Centromere / immunology
Coronary Circulation
Dyspnea / etiology
Furosemide / therapeutic use
Heart Failure / drug therapy,  etiology*,  radionuclide imaging
Isosorbide Dinitrate / therapeutic use
Liver Cirrhosis, Biliary / complications*,  diagnosis
Microsomes, Liver / immunology
Middle Aged
Nitroglycerin / therapeutic use
Raynaud Disease / etiology
Scleroderma, Systemic / complications*,  diagnosis
Skin / pathology
Thallium Radioisotopes / therapeutic use
Reg. No./Substance:
0/Autoantibodies; 0/Thallium Radioisotopes; 54-31-9/Furosemide; 55-63-0/Nitroglycerin; 87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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