Document Detail

Acute conduction velocity changes in guinea-pigs after administration of diphenylhydantoin.
MedLine Citation:
PMID:  1003245     Owner:  NLM     Status:  MEDLINE    
Motor nerve conduction velocity was measured after dosing guinea-pigs with 200-400 μmol/kg diphenylhydantoin (DPH) daily for three to four days. Conduction velocity fell by a mean value of 13% in animals that achieved plasma DPH levels over 200 μmol/l. There was no change in velocity with DPH levels below this value.
P M Le Quesne; V Goldberg; F Vajda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  39     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2012-05-30    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  995-1000     Citation Subset:  IM    
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MeSH Terms
Depression, Chemical
Guinea Pigs
Neural Conduction / drug effects*
Phenytoin / pharmacology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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