Document Detail

Acute complications of dopamine agonist treatment for macroprolactinoma - how uncommon?
MedLine Citation:
PMID:  15519856     Owner:  NLM     Status:  MEDLINE    
Dopamine agonists are first line treatment for prolactinomas. This treatment can cause serious complications in patients with invasive macroprolactinomas. This study reviewed 195 patients attending the endocrine clinic and/or undergoing surgery for pituitary tumours at The Royal Melbourne Hospital in a seven-year period (1996-2002). Thirty three patients had macroprolactinoma (diameter >10 mm). Eleven of them were treated with dopamine agonist prior to surgery and four developed severe complications. This study suggests that the severe complications of dopamine agonist therapy may be higher than previously reported. All patients should be educated about these complications and their early recognition.
Subanesan Nadesapillai; Inga Balcere; Andrew H Kaye; Brian M Tress; Peter G Colman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  11     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-02     Completed Date:  2008-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  825-8     Citation Subset:  IM    
Department of Diabetes and Endocrinology, The University of Melbourne, Australia.
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MeSH Terms
Dopamine Agonists / adverse effects*,  therapeutic use*
Hormones / metabolism
Middle Aged
Prolactinoma / drug therapy*,  metabolism,  pathology,  surgery
Retrospective Studies
Time Factors
Reg. No./Substance:
0/Dopamine Agonists; 0/Hormones

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