| Acute combined effects of HCN and CO, with the use of combustion products from PAN (polyacrylonitrile)--gauze mistures. | |
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MedLine Citation:
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PMID: 1007632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The combustion product from gauze-PAN (Polyacrylonitrile) micture was used as a material for the evaluation of the combined effects of CO and HCN. Rats and mice were exposed for 30 min. to the combustion products. In mice experiments, the time at which animals turned laterally and were killed, was measured. In experiments with rats, blood COHb and cyanide determinations were made, in addition to the observation of the behavior. Exposure room gas concentrations (O2, CO2, CO, HCN) were determined and temperature in the combustion room was measured during heating. Preliminary experiments with PAN, ranging from 2g to 10g, on mice showed that HCN is responsible for the toxicity of the combustion products from this fiber. In mixture experiments all animals died during exposure. In experiments with mice (8g of total weight of mixed sample), animals in groups with larger proportion of PAN turned over and died earlier and this was explained by higher HCN concentration. In rats experiments (10g), this held true for severe impairment, however, as to the death time, this was not the case. There was a long interval between severe impairment and death in groups with larger proportion of PAN. The larger amount of HCN was produced as temperature rises. A linear relation between COHb concentration and CT (concentration-time) product was shown. There was not a linear relation between blood COHb and cyanide levels. Judging from the blood analyses data, it seemed probable that there is neither an additive nor a synergistic action between CO and HCN with respect to lethal effects. |
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Authors:
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K Yamamoto |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zeitschrift für Rechtsmedizin. Journal of legal medicine Volume: 78 ISSN: 0044-3433 ISO Abbreviation: Z. Rechtsmed. Publication Date: 1976 |
Date Detail:
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Created Date: 1977-02-16 Completed Date: 1977-02-16 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 0247437 Medline TA: Z Rechtsmed Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 303-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylonitrile
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adverse effects* Air Pollution Animals Carbon Monoxide / adverse effects* Cyanides / adverse effects* Fires Maximum Allowable Concentration Mice Nitriles / adverse effects* Rats Temperature |
| Chemical | |
Reg. No./Substance:
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0/Cyanides; 0/Nitriles; 107-13-1/Acrylonitrile; 630-08-0/Carbon Monoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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