Document Detail

Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area.
MedLine Citation:
PMID:  17686047     Owner:  NLM     Status:  MEDLINE    
Growing evidence indicates that the expression of synaptic plasticity in the central nervous system results in dendritic reorganization and spine remodeling. Although long-term potentiation of glutamatergic synapses after cocaine exposure in the ventral tegmental area (VTA) has been proposed as a cellular mechanism underlying addictive behaviors, the relationship between long-term potentiation and dendritic remodeling induced by cocaine on the dopaminergic neurons of the VTA has not been demonstrated. Here we report that rat VTA cells classified as type I and II showed distinct morphological responses to cocaine, as a single cocaine exposure significantly increased dendritic spine density in type I but not in type II cells. Further, only type I cells had a significant increase in the AMPA receptor:NMDA receptor ratio after a single cocaine exposure. Taken together, our data provide evidence that increased spine density and synaptic plasticity are coexpressed within the same VTA neuronal population and that only type I neurons are structurally and synaptically modified by cocaine.
Federica Sarti; Stephanie L Borgland; Viktor N Kharazia; Antonello Bonci
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  26     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-09     Completed Date:  2007-10-17     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  749-56     Citation Subset:  IM    
Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite #200, Emeryville, San Francisco, CA 94608, USA.
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MeSH Terms
Action Potentials / drug effects
Cell Shape / drug effects
Cocaine / pharmacology*
Cocaine-Related Disorders / pathology,  physiopathology*
Dendritic Spines / drug effects*,  pathology
Dopamine / metabolism
Dopamine Uptake Inhibitors / pharmacology
Glutamic Acid / metabolism
Long-Term Potentiation / drug effects*
Lysine / analogs & derivatives
Organ Culture Techniques
Patch-Clamp Techniques
Rats, Sprague-Dawley
Receptors, AMPA / drug effects,  metabolism
Receptors, N-Methyl-D-Aspartate / drug effects,  metabolism
Staining and Labeling
Synapses / drug effects,  pathology
Synaptic Transmission / drug effects
Ventral Tegmental Area / drug effects*,  pathology,  physiopathology*
Grant Support
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 0/Receptors, AMPA; 0/Receptors, N-Methyl-D-Aspartate; 50-36-2/Cocaine; 56-86-0/Glutamic Acid; 56-87-1/Lysine; 576-19-2/biocytin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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