Document Detail

Acute and chronic sympathoinhibition on carotid artery diameter of spontaneously hypertensive rats: effects of clonidine and flesinoxan.
MedLine Citation:
PMID:  10972539     Owner:  NLM     Status:  MEDLINE    
1. Hypertensive conduit arteries are thicker and stiffer than those of normotensive controls. Whether they are specifically sensitive to central sympathoinhibition has never been investigated. 2. The effects of acute (24 h infusion) and chronic (4 week infusion) treatments with clonidine (0.01 and 0.1 mg/kg per day) and flesinoxan (1 and 3 mg/kg per day) on carotid artery diameter were investigated in spontaneously hypertensive rats. At the end of treatment, blood pressure (BP) was recorded in the rats while they were conscious. Rats were then anaesthetized for carotid artery diameter measurements using an ultrasonic echotracking device. 3. In conscious rats, clonidine significantly decreased BP and heart rate (HR) following acute but not chronic treatment. In contrast, flesinoxan significantly decreased BP following both the acute and chronic treatment. In anaesthetized animals, the two agents have opposite effects on isobaric carotid artery diameter, with a decrease under clonidine and an increase under flesinoxan. After 4 weeks infusion, the reactivity of aortic rings was studied in organ chambers. Flesinoxan, but not clonidine, caused the relaxation of potassium chloride precontracted aortic segments. 4. The results indicate that although clonidine and flesinoxan are centrally acting antihypertensive agents, the drug-induced changes in isobaric carotid diameter may be influenced by local factors independent of the central action of the two drugs.
H Dabiré; P Chamiot-Clerc; K Chaouche-Teyara; B Fournier; M E Safar
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  27     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-12     Completed Date:  2000-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  715-23     Citation Subset:  IM    
Institut National de la Santé et de la Recherche Médicale U337, Paris, France.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology*
Antihypertensive Agents / pharmacology
Aorta, Abdominal / drug effects
Blood Pressure / drug effects
Carotid Arteries / anatomy & histology,  drug effects*,  physiopathology
Clonidine / pharmacology*
Drug Administration Schedule
Heart Rate / drug effects
Hypertension / drug therapy,  physiopathology
Infusions, Intravenous
Norepinephrine / pharmacology
Piperazines / pharmacology*
Potassium Chloride / pharmacology
Rats, Inbred SHR
Receptors, Adrenergic, alpha-2 / agonists
Receptors, Serotonin / physiology
Receptors, Serotonin, 5-HT1
Serotonin Agonists / pharmacology*
Sympathetic Nervous System / drug effects*
Sympatholytics / pharmacology*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Antihypertensive Agents; 0/Piperazines; 0/Receptors, Adrenergic, alpha-2; 0/Receptors, Serotonin; 0/Receptors, Serotonin, 5-HT1; 0/Serotonin Agonists; 0/Sympatholytics; 4205-90-7/Clonidine; 51-41-2/Norepinephrine; 7447-40-7/Potassium Chloride; 98206-10-1/flesinoxan

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