| Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity. | |
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MedLine Citation:
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PMID: 20620030 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Using the rodent activity-based anorexia (ABA) model that mimics clinical features of anorexia nervosa that include food restriction-induced hyperlocomotion, we found that plasma ghrelin levels are highly associated with food anticipatory behaviour, measured by running wheel activity in rats. Furthermore, we showed that ghrelin receptor (GHS-R1A) knockout mice do not anticipate food when exposed to the ABA model, unlike their wild type littermate controls. Likewise, food anticipatory activity in the ABA model was suppressed by a GHS-R1A antagonist administered either by acute central (ICV) injection to rats or by chronic peripheral treatment to mice. Interestingly, the GHS-R1A antagonist did not alter food intake in any of these models. Therefore, we hypothesize that suppression of the central ghrelin signaling system via GHS-R1A provides an interesting therapeutic target to treat hyperactivity in patients suffering from anorexia nervosa. |
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Authors:
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Linda A W Verhagen; Emil Egecioglu; Mieneke C M Luijendijk; Jacquelien J G Hillebrand; Roger A H Adan; Suzanne L Dickson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Volume: 21 ISSN: 1873-7862 ISO Abbreviation: Eur Neuropsychopharmacol Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111390 Medline TA: Eur Neuropsychopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 384-92 Citation Subset: IM |
Copyright Information:
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Copyright © 2010. Published by Elsevier B.V. |
Affiliation:
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Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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