Document Detail


Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity.
MedLine Citation:
PMID:  20620030     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Using the rodent activity-based anorexia (ABA) model that mimics clinical features of anorexia nervosa that include food restriction-induced hyperlocomotion, we found that plasma ghrelin levels are highly associated with food anticipatory behaviour, measured by running wheel activity in rats. Furthermore, we showed that ghrelin receptor (GHS-R1A) knockout mice do not anticipate food when exposed to the ABA model, unlike their wild type littermate controls. Likewise, food anticipatory activity in the ABA model was suppressed by a GHS-R1A antagonist administered either by acute central (ICV) injection to rats or by chronic peripheral treatment to mice. Interestingly, the GHS-R1A antagonist did not alter food intake in any of these models. Therefore, we hypothesize that suppression of the central ghrelin signaling system via GHS-R1A provides an interesting therapeutic target to treat hyperactivity in patients suffering from anorexia nervosa.
Authors:
Linda A W Verhagen; Emil Egecioglu; Mieneke C M Luijendijk; Jacquelien J G Hillebrand; Roger A H Adan; Suzanne L Dickson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology     Volume:  21     ISSN:  1873-7862     ISO Abbreviation:  Eur Neuropsychopharmacol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111390     Medline TA:  Eur Neuropsychopharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  384-92     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier B.V.
Affiliation:
Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Utrecht, The Netherlands.
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