Document Detail


Acute and chronic responses of the upper airway to inspiratory loading in healthy awake humans: an MRI study.
MedLine Citation:
PMID:  17341450     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed upper airway responses to acute and chronic inspiratory loading. In Experiment I, 11 healthy subjects underwent T(2)-weighted magnetic resonance imaging (MRI) of upper airway dilator muscles (genioglossus and geniohyoid) before and up to 10 min after a single bout of pressure threshold inspiratory muscle training (IMT) at 60% maximal inspiratory mouth pressure (MIP). T(2) values for genioglossus and geniohyoid were increased versus control (p<0.001), suggesting that these airway dilator muscles are activated in response to acute IMT. In Experiment II, nine subjects underwent 2D-Flash sequence MRI of the upper airway during quiet breathing and while performing single inspirations against resistive loads (10%, 30% and 50% MIP); this procedure was repeated after 6 weeks of IMT. Lateral narrowing of the upper airway occurred at all loads, whilst anteroposterior narrowing occurred at the level of the laryngopharynx at loads > or =30% MIP. Changes in upper airway morphology and narrowing after IMT were undetectable using MRI.
Authors:
Stephen C How; Alison K McConnell; Bryan J Taylor; Lee M Romer
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-20
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  157     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-08-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  270-80     Citation Subset:  IM    
Affiliation:
Centre for Sports Medicine and Human Performance, School of Sport and Education, Brunel University, Uxbridge, Middlesex UB8 3PH, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Airway Resistance / physiology*
Breathing Exercises
Female
Humans
Inhalation / physiology*
Magnetic Resonance Imaging*
Male
Mouth Breathing
Respiratory Muscles / physiology
Respiratory Physiological Phenomena*
Respiratory System / anatomy & histology*
Time Factors
Wakefulness / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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