Document Detail

Acute and chronic post-surgical pain after live liver donation: Incidence and predictors.
MedLine Citation:
PMID:  25045167     Owner:  NLM     Status:  Publisher    
Despite its prominence as a concern among potential surgical candidates, there is little information in the literature regarding the short- and long-term pain experience after live liver donation. We undertook a prospective study to examine: (1) the nature and incidence of acute and chronic pain after live donor hepatectomy, and (2) the factors associated an increased or decreased risk of adverse pain outcomes. Prior to donation, a comprehensive assessment of potential predictors of acute and chronic pain outcomes was conducted, including donors' pain expectations, psychosocial factors, medical history, and demographic factors. Detailed data regarding pain outcomes was collected post-operatively (day one and day two), and again at a six- and twelve-month follow-up telephone interview. A total of 65 adults (33 female, 32 male) scheduled for a donor hepatectomy participated. A substantial proportion of donors reported a moderate-to-severe level of pain intensity (> 4 on a 0-10 scale) at rest and at movement on day one (42%, 74%) and day two (33%, 32%). Persistent post-surgical pain was reported by 31% of donors at the six-month follow-up and by 27% of donors at the twelve-month follow-up. Generally, this pain was mild and pain-related life interference was minimal. Female gender, younger age, and several pre-donation measures of pain-related anxiety were associated with a significantly greater risk of developing persistent post-surgical pain. This study identifies a subset of patients who experience persistent pain after live liver donation. Additional prospective research using larger samples of liver donors is needed to replicate this work, to obtain a more detailed account of the acute and long-term pain experience, and to determine if targeted interventions can minimize the frequency and severity of chronic pain. Liver Transpl , 2014. © 2014 AASLD.
Susan Holtzman; Hance A Clarke; Stuart A McCluskey; Kara Turcotte; David Grant; Joel Katz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-5
Journal Detail:
Title:  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society     Volume:  -     ISSN:  1527-6473     ISO Abbreviation:  Liver Transpl.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909185     Medline TA:  Liver Transpl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©2014. American Association for the Study of Liver Diseases.
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