| Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions. | |
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MedLine Citation:
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PMID: 21780899 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In recent years, acute-on-chronic liver failure has been recognized as a specific clinical form of liver failure associated with cirrhosis. The syndrome refers to an acute deterioration of liver function and subsequently of other end organs over a period of weeks following a precipitating event in a patient with previously well- or reasonably well-compensated cirrhosis. These precipitating events include either an indirect (e.g., variceal hemorrhage, sepsis) or a direct (e.g., drug-induced) hepatotoxic factor. The short-term mortality for this condition is more than 50%. At present, considerable efforts are ongoing to better characterize the syndrome, to gain further insight into its pathophysiology and to optimize therapy. This article aims to highlight the current concepts of these various aspects. |
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Authors:
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Wim Laleman; Len Verbeke; Philippe Meersseman; Joost Wauters; Jos van Pelt; David Cassiman; Alexander Wilmer; Chris Verslype; Frederik Nevens |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of gastroenterology & hepatology Volume: 5 ISSN: 1747-4132 ISO Abbreviation: Expert Rev Gastroenterol Hepatol Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278199 Medline TA: Expert Rev Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 523-37 Citation Subset: IM |
Affiliation:
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Department of Liver and Biliopancreatic disorders, University Hospital Gasthuisberg, KU Leuven, B-3000 Leuven, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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