Document Detail

Acute and chronic isosorbide dinitrate therapy in congestive heart failure: demonstration of improved exercise capacity and differing arterial and venous tolerance during chronic administration.
MedLine Citation:
PMID:  6666218     Owner:  NLM     Status:  MEDLINE    
Thirty patients with congestive heart failure underwent a double-blind study after randomization into either isosorbide dinitrate or placebo. The initial dose (40 mg orally) of isosorbide dinitrate reduced resting and exercise pulmonary artery, pulmonary capillary wedge, and systemic blood pressure and pulmonary and systemic vascular resistance without improving exercise tolerance. Chronic dosing (40 mg orally every 6 h for 3 months) increased exercise tolerance and maintained a reduction in resting and exercise pulmonary artery and pulmonary capillary wedge pressures and pulmonary resistance, while systemic pressure and resistance returned to baseline. Chronic oral isosorbide dinitrate (40 mg every 6 h) improves exercise capacity over a 3-month period with disparate tolerance effects on systemic arterial, systemic venous, and pulmonary vasculature.
C V Leier; P Huss; R D Magorien; D V Unverferth
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Zeitschrift für Kardiologie     Volume:  72 Suppl 3     ISSN:  0300-5860     ISO Abbreviation:  Z Kardiol     Publication Date:  1983  
Date Detail:
Created Date:  1984-03-21     Completed Date:  1984-03-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0360430     Medline TA:  Z Kardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
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MeSH Terms
Heart Failure / drug therapy*,  physiopathology
Isosorbide Dinitrate / administration & dosage,  therapeutic use*
Physical Exertion
Pulmonary Wedge Pressure / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
87-33-2/Isosorbide Dinitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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