Document Detail


Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats.
MedLine Citation:
PMID:  20655988     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Exercise stimulates the release of beta-endorphin and other endogenous opioid peptides that are believed to be responsible for changes in mood, perception of pain and also performance. Although the vast majority of literature data support the role of physical exercise in increasing beta-endorphin levels, indirect measures such as increased endorphin levels in peripheral blood do not reflect opioid levels in the central nervous system. The purpose of the present study was to verify whether acute and chronic exercise using both voluntary and forced exercise procedures could modify the expression of μ-opioid receptors (MOR) in rat hippocampal formation. Immunoblotting analysis showed significantly enhanced MOR expression in the hippocampal formation in the acute (forced and voluntary) exercise groups when compared to the control group. Conversely, a significant reduction of MOR expression was noted in the chronic forced and chronic voluntary exercise groups compared to the acute forced and voluntary groups respectively. MOR expression was not significantly different in rats trained using both acute or chronic exercise. Immunohistochemistry analysis showed a higher number of MOR-positive cells for acute forced and voluntary exercise groups in the CA1, CA3, hilus and dentate gyrus regions compared to the control group. Our findings indicate that acute and chronic exercise modulates MOR expression in the hippocampal formation of rats.
Authors:
Mônica Sílvia Rodrigues de Oliveira; Maria José da Silva Fernandes; Fulvio Alexandre Scorza; Danielle Suzete Persike; Carla Alessandra Scorza; Jaqueline Botelho da Ponte; Marly de Albuquerque; Esper Abrão Cavalheiro; Ricardo Mario Arida
Related Documents :
1523268 - Pnmt inhibition decreases exercise performance in the rat.
17271078 - Effects of interleukin-2 on the mechanical restitution and post-rest contraction in rat...
9421378 - Effect of exercise training and food restriction on endothelium-dependent relaxation in...
10447208 - Running exercise increases tumor necrosis factor-alpha secreting from mesenteric fat in...
7197628 - Specificity of the anaerobic threshold in endurance trained cyclists and runners.
14583168 - In their own voices: definitions and interpretations of physical activity.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-23
Journal Detail:
Title:  Brain research bulletin     Volume:  83     ISSN:  1873-2747     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Universidade de Mogi das Cruzes, São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
Next Document:  Myricetin reduces voltage activated potassium channel currents in DRG neurons by a p38 dependent mec...