| Acute and chronic efficacy of felodipine in congestive heart failure. | |
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MedLine Citation:
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PMID: 1991673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 13 patients with congestive heart failure we tested the acute hemodynamic effects of 5 vs. 10 mg felodipine tablets, in a double-blind, cross-over study. One hour after felodipine 5 mg, echocardiographic ejection fraction (%), cardiac index (thermodilution-ml/min/m2), and pulmonary wedge pressure (mm Hg) significantly changed (from 21 +/- 2 to 26 +/- 2, 2350 +/- 150 to 2790 +/- 160, 24 +/- 4 to 17 +/- 4) while they remained steady after felodipine 10 mg. The greatest stroke index increases were associated with felodipine 5 mg in 12 patients and 10 mg in 1 patient. Therefore we evaluated (open study) the long-term (2 months- 1 year) clinical and hemodynamic efficacy following the treatment with the acutely most effective dose (twice daily). After 2 months ejection fraction, cardiac index and pulmonary wedge pressure were respectively 24 +/- 2, 2550 +/- 150, and 18 +/- 4 (12 hours after the last drug administration, n = 11, P less than 0.02 from baseline). These parameters further increased one to two hours after the following administration of felodipine. Clinical improvement (reduction of 1 functional class, according to the New York Heart Association) was observed in 8/13 patients. These 8 patients participated to the one year follow-up. In 5 patients follow-up was interrupted because of acute cardiovascular events. However, before study interruption (5 patients) or ending (3 patients) clinical status did not worsen and ejection fraction remained higher than in the pretreatment period. Therefore, low dose felodipine might be used in the treatment of congestive heart failure. |
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Authors:
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P Agostoni; E Doria; S Riva; A Polese |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of cardiology Volume: 30 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-03-08 Completed Date: 1991-03-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 89-95 Citation Subset: IM |
Affiliation:
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Istituto di Cardiologia, University of Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Double-Blind Method Felodipine / administration & dosage, therapeutic use* Female Follow-Up Studies Heart Failure / drug therapy*, physiopathology Hemodynamics / drug effects* Humans Male Middle Aged Time Factors |
| Chemical | |
Reg. No./Substance:
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72509-76-3/Felodipine |
| Comments/Corrections | |
Comment In:
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Int J Cardiol. 1991 Aug;32(2):267
[PMID:
1833347
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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