Document Detail

Acute and chronic effects of vinpocetine on cerebral hemodynamics and neuropsychological performance in multi-infarct patients.
MedLine Citation:
PMID:  16100299     Owner:  NLM     Status:  MEDLINE    
A double-blind, prospective, randomized, placebo-controlled clinical trial was carried out to test the acute and long-term hemodynamical and beneficial cognitive effects of the vasoactive agent vinpocetine on patients suffering from multiple cerebral infarcts by means of functional transcranial Doppler examinations and by neuropsychological tests. Twenty-six patients (17 men, 9 women) with multiple cerebral infarctions, aged between 50 and 83 years (mean age+/-SD=63.4+/-9.39 years) were examined, 14 of whom received vinpocetine and 12 placebo. The functional transcranial Doppler included breath-holding tests, finger movement, word fluency, and picture-discrimination tasks. Twenty-five patients were assessed by neuropsychological battery. No serious side effect was found in the vinpocetine group. The flow velocities were significantly lower in the acute phase after breath holding in the vinpocetine group than in the placebo group. Three months later, the vinpocetine patients did not show any significant worsening in digit span backward test, while the placebo group did. No other significant differences in the neuropsychological test could be detected between the treatment and the placebo groups. Longer lasting and higher dosage of vinpocetine therapy is suggested to prove its potential effect.
Vendel Kemény; Sándor Molnár; Mónika Andrejkovics; Attila Makai; László Csiba
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  45     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-15     Completed Date:  2006-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1048-54     Citation Subset:  IM    
Department of Neurology, PM Flór Ferenc County Hospital, H-2143 Kistarcsa, and Department of Neurology, University of Debrecen, Hungary.
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MeSH Terms
Aged, 80 and over
Brain / blood supply,  drug effects*,  physiology
Cerebral Infarction / drug therapy*
Cerebrovascular Circulation / drug effects
Double-Blind Method
Middle Aged
Neuroprotective Agents / therapeutic use*
Neuropsychological Tests
Nootropic Agents / therapeutic use*
Time Factors
Vinca Alkaloids / therapeutic use*
Reg. No./Substance:
0/Neuroprotective Agents; 0/Nootropic Agents; 0/Vinca Alkaloids; 42971-12-0/vinpocetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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