Document Detail


Acute and chronic effects of nicardipine on rest and exercise haemodynamics in post-myocardial infarction patients with latent cardiac failure.
MedLine Citation:
PMID:  2668004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acute and chronic haemodynamic effects of nicardipine were studied, at rest and during exercise, in 10 post-myocardial infarction patients with latent cardiac failure and no signs of residual myocardial ischaemia. Intravenous administration of nicardipine (5 mg over 10 min) was associated with a significant increase in cardiac index and significant reductions in mean pulmonary artery pressure, mean pulmonary wedge pressure, total pulmonary resistance and systemic vascular resistance under conditions of rest and peak exercise. After 3 weeks of oral treatment (20 mg three times daily) cardiac index did not change, but the improvements in mean pulmonary artery pressure, mean pulmonary wedge pressure and total pulmonary resistance were sustained at rest and during exercise, at the same workload attained prior to medication. Chronic treatment with nicardipine significantly increased exercise tolerance, while mean pulmonary artery pressure, mean pulmonary wedge pressure and total pulmonary resistance were maintained below the control values. It is concluded that nicardipine improves both rest and exercise cardiac performance in post-myocardial infarction patients with latent cardiac failure, thus avoiding the risk of pulmonary congestion.
Authors:
M T La Rovere; A Mortara; C Opasich; G Specchia
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  10     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-09-08     Completed Date:  1989-09-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  429-36     Citation Subset:  IM    
Affiliation:
Divisione di Cardiologia Centro Medico Montescano Fondazione Clinica del Lavoro IRCCS, Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic
Exercise Test*
Heart Failure / prevention & control*
Hemodynamics / drug effects*
Humans
Male
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology
Nicardipine / pharmacology,  therapeutic use*
Rest
Chemical
Reg. No./Substance:
55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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